The article reviews the potential of silver nanoparticles (AgNPs) as antibacterial agents, particularly in addressing the growing problem of antibiotic resistance. Silver has a long history of use in medicine due to its potent antibacterial properties, and AgNPs have gained attention for their broad-spectrum antimicrobial activity. The review highlights the mechanisms by which AgNPs interact with and kill bacteria, including damage to cell membranes, disruption of protein synthesis, and induction of reactive oxygen species (ROS). The antibacterial effects of AgNPs are influenced by their size, shape, and concentration, with smaller nanoparticles being more effective against Gram-negative bacteria. The article also discusses the synergistic effects of combining AgNPs with antibiotics, which can enhance their antimicrobial activity and reduce the required dosage of antibiotics. Additionally, the review explores the antibiofilm activity of AgNPs, which is crucial for preventing infections in medical devices and chronic infections. The structural differences between Gram-positive and Gram-negative bacteria affect the effectiveness of AgNPs, with Gram-negative bacteria being more resistant due to their thicker cell walls. The article concludes by emphasizing the need for further research to understand the mechanisms of action of AgNPs and to optimize their use in clinical settings.The article reviews the potential of silver nanoparticles (AgNPs) as antibacterial agents, particularly in addressing the growing problem of antibiotic resistance. Silver has a long history of use in medicine due to its potent antibacterial properties, and AgNPs have gained attention for their broad-spectrum antimicrobial activity. The review highlights the mechanisms by which AgNPs interact with and kill bacteria, including damage to cell membranes, disruption of protein synthesis, and induction of reactive oxygen species (ROS). The antibacterial effects of AgNPs are influenced by their size, shape, and concentration, with smaller nanoparticles being more effective against Gram-negative bacteria. The article also discusses the synergistic effects of combining AgNPs with antibiotics, which can enhance their antimicrobial activity and reduce the required dosage of antibiotics. Additionally, the review explores the antibiofilm activity of AgNPs, which is crucial for preventing infections in medical devices and chronic infections. The structural differences between Gram-positive and Gram-negative bacteria affect the effectiveness of AgNPs, with Gram-negative bacteria being more resistant due to their thicker cell walls. The article concludes by emphasizing the need for further research to understand the mechanisms of action of AgNPs and to optimize their use in clinical settings.