This study aims to optimize the deacetylation process of chitosan from shrimp waste to achieve high deacetylation degrees and molar masses. The research was conducted using a central composite design, considering three parameters: NaOH concentration, liquid:solid ratio, and process duration. Regression models were developed for the deacetylation degree (DD) and mean molar mass (MM) of chitosan powders. Multiobjective optimization problems were formulated to maximize DD and either maximize or minimize MM. Genetic algorithms implemented in Matlab were used to solve these problems, resulting in multiple optimal solutions that represent trade-offs between the two objectives. The study found that higher NaOH concentrations and moderate durations were favorable for high DD and MM, while longer durations and slightly lower NaOH concentrations were recommended for high DD and low MM. The results provide valuable insights for optimizing the deacetylation process to produce chitosan with desired properties for various applications.This study aims to optimize the deacetylation process of chitosan from shrimp waste to achieve high deacetylation degrees and molar masses. The research was conducted using a central composite design, considering three parameters: NaOH concentration, liquid:solid ratio, and process duration. Regression models were developed for the deacetylation degree (DD) and mean molar mass (MM) of chitosan powders. Multiobjective optimization problems were formulated to maximize DD and either maximize or minimize MM. Genetic algorithms implemented in Matlab were used to solve these problems, resulting in multiple optimal solutions that represent trade-offs between the two objectives. The study found that higher NaOH concentrations and moderate durations were favorable for high DD and MM, while longer durations and slightly lower NaOH concentrations were recommended for high DD and low MM. The results provide valuable insights for optimizing the deacetylation process to produce chitosan with desired properties for various applications.