This paper reports the first realization of single-shot readout for a nuclear spin in silicon carbide (SiC). The authors achieve a deterministic readout fidelity of 98.2% with a measurement duration of 1.13 ms using a dual-step readout scheme, which further improves the fidelity to 99.5% with a success efficiency of 89.8%. The study focuses on a next-nearest-neighbor (NNN) $^{29}$Si nuclear spin strongly coupled with a k-site silicon vacancy (V2) center in commercial natural abundance 4H-SiC. The V2 center is created by electron irradiation and post-annealing, and the sample is placed in a 4 K cryostat. The external magnetic field is 942 G, and the V2 center electron Zeeman splitting is much larger than the electron-nuclear hyperfine splitting, suppressing the flip-flop process between electron and nuclear spins. The energy level structure of the V2 center and the ground states level structure of the V2 center strongly coupled with a single nuclear spin under the external magnetic field are detailed. The optical and spin coherence of the V2 center are characterized, and the fidelity of the MW3A π-pulse is about 96.7±0.4%. The T2* coherence time of the nuclear spin is 9.9±1.2 ms, confirming its long coherence time. The paper also discusses methods to improve the readout fidelity, such as isotope engineering and coupling the V2 center to nanostructures. The results demonstrate the potential for high-fidelity nuclear photon entanglement with long lifetime, making SiC a promising candidate for quantum networks.This paper reports the first realization of single-shot readout for a nuclear spin in silicon carbide (SiC). The authors achieve a deterministic readout fidelity of 98.2% with a measurement duration of 1.13 ms using a dual-step readout scheme, which further improves the fidelity to 99.5% with a success efficiency of 89.8%. The study focuses on a next-nearest-neighbor (NNN) $^{29}$Si nuclear spin strongly coupled with a k-site silicon vacancy (V2) center in commercial natural abundance 4H-SiC. The V2 center is created by electron irradiation and post-annealing, and the sample is placed in a 4 K cryostat. The external magnetic field is 942 G, and the V2 center electron Zeeman splitting is much larger than the electron-nuclear hyperfine splitting, suppressing the flip-flop process between electron and nuclear spins. The energy level structure of the V2 center and the ground states level structure of the V2 center strongly coupled with a single nuclear spin under the external magnetic field are detailed. The optical and spin coherence of the V2 center are characterized, and the fidelity of the MW3A π-pulse is about 96.7±0.4%. The T2* coherence time of the nuclear spin is 9.9±1.2 ms, confirming its long coherence time. The paper also discusses methods to improve the readout fidelity, such as isotope engineering and coupling the V2 center to nanostructures. The results demonstrate the potential for high-fidelity nuclear photon entanglement with long lifetime, making SiC a promising candidate for quantum networks.