The article presents a novel biomimetic-nanozyme amyloid hydrogel as an effective oral platform for alcohol detoxification. The hydrogel is composed of atomically dispersed iron anchored to β-lactoglobulin (BLG) fibrils, which mimic the structure and function of horseradish peroxidase. This design allows the hydrogel to selectively catalyze the oxidation of alcohol into acetic acid, reducing blood alcohol levels by 55.8% 300 minutes post-alcohol intake without causing additional acetaldehyde accumulation. The hydrogel also demonstrates protective effects on the liver and mitigates intestinal damage and dysbiosis associated with chronic alcohol consumption. The study highlights the potential of this biomimetic-nanozyme hydrogel as a promising therapeutic approach for alcohol-related conditions.The article presents a novel biomimetic-nanozyme amyloid hydrogel as an effective oral platform for alcohol detoxification. The hydrogel is composed of atomically dispersed iron anchored to β-lactoglobulin (BLG) fibrils, which mimic the structure and function of horseradish peroxidase. This design allows the hydrogel to selectively catalyze the oxidation of alcohol into acetic acid, reducing blood alcohol levels by 55.8% 300 minutes post-alcohol intake without causing additional acetaldehyde accumulation. The hydrogel also demonstrates protective effects on the liver and mitigates intestinal damage and dysbiosis associated with chronic alcohol consumption. The study highlights the potential of this biomimetic-nanozyme hydrogel as a promising therapeutic approach for alcohol-related conditions.