The study aims to explore the implementation of Hospital Information Systems (HIS) to enhance the efficiency of healthcare services. The research design is a literature review focusing on Hospital Information Systems supporting hospital services, using databases such as PUBMED, Sciencedirect, Researchgate, and Google Scholar, covering the period from 2010 to 2020. The data collection is structured thematically based on the concept of thinking, using keywords like "hospital information system," "information system efficiency," and "healthcare efficiency." The results indicate that Hospital Information Systems can minimize the complexity of healthcare services by increasing organizational efficiency through innovations in business process management, service automation, cost reduction, and improved hospital performance. This aims to develop human resources, organizational development, and technological quality improvement to achieve efficiency in healthcare services. The study concludes that Hospital Information Systems are crucial for supporting healthcare services and improving quality, effectiveness, and efficiency, with a focus on human, organizational, and technological development.The study aims to explore the implementation of Hospital Information Systems (HIS) to enhance the efficiency of healthcare services. The research design is a literature review focusing on Hospital Information Systems supporting hospital services, using databases such as PUBMED, Sciencedirect, Researchgate, and Google Scholar, covering the period from 2010 to 2020. The data collection is structured thematically based on the concept of thinking, using keywords like "hospital information system," "information system efficiency," and "healthcare efficiency." The results indicate that Hospital Information Systems can minimize the complexity of healthcare services by increasing organizational efficiency through innovations in business process management, service automation, cost reduction, and improved hospital performance. This aims to develop human resources, organizational development, and technological quality improvement to achieve efficiency in healthcare services. The study concludes that Hospital Information Systems are crucial for supporting healthcare services and improving quality, effectiveness, and efficiency, with a focus on human, organizational, and technological development.