This article presents a skin-inspired highly stretchable and conformable matrix network (SCMN) for multifunctional sensing. The SCMN is designed to detect and quantify various stimuli, including temperature, in-plane strain, humidity, light, magnetic field, pressure, and proximity. The SCMN consists of a structured polyimide network with integrated sensor units that can be expanded in three-dimensional (3D) configurations, enabling simultaneous multi-stimulus sensing and adjustable sensing ranges. The SCMN is demonstrated in a personalized intelligent prosthetic hand that can perform real-time spatial pressure mapping and temperature estimation. The SCMN is also shown to have broad applications in humanoid robotics, new prosthetics, human-machine interfaces, and health-monitoring technologies. The human somatosensory system converts environmental stimuli into electrical impulses through various sensory receptors and neural pathways, enabling sensations of touch, heat/cold, and pain. Mechanosensation electronics (e-skin) mimic this system by detecting and quantifying various stimuli in the ambient environment. E-skin has attracted significant attention for its revolutionary applications in robotics, prosthetics, and health-monitoring technologies. The ability to sense multiple stimuli is an ultimate goal for e-skin systems, but previous reports have mainly focused on single or dual sensory capabilities. The SCMN overcomes this limitation by integrating multiple sensor units into a single network, enabling simultaneous detection and high selectivity of multi-complex stimuli from the ambient environment. The SCMN is composed of 100 sensory nodes connected by meandering wires, allowing for high flexibility and stretchability. The SCMN is tested for its stretchability and expandability, showing excellent performance under various conditions. The SCMN is also demonstrated for temperature sensing, in-plane strain sensing, humidity sensing, light sensing, magnetic field sensing, pressure and proximity sensing, and simultaneous multi-stimulus sensing. The SCMN is shown to have adjustable sensing ranges and large-area expandability, making it suitable for high-density 3D integration schemes. The SCMN is also demonstrated in a personalized intelligent prosthetic hand that can perform real-time spatial pressure mapping and temperature estimation. The SCMN is shown to have broad applications in humanoid robotics, new prosthetics, human-machine interfaces, and health-monitoring technologies. The SCMN is a significant advancement in mechanosensation electronics towards the Internet of 'actions' (IoA), which is expected to revolutionize healthcare, medical science, and robotics.This article presents a skin-inspired highly stretchable and conformable matrix network (SCMN) for multifunctional sensing. The SCMN is designed to detect and quantify various stimuli, including temperature, in-plane strain, humidity, light, magnetic field, pressure, and proximity. The SCMN consists of a structured polyimide network with integrated sensor units that can be expanded in three-dimensional (3D) configurations, enabling simultaneous multi-stimulus sensing and adjustable sensing ranges. The SCMN is demonstrated in a personalized intelligent prosthetic hand that can perform real-time spatial pressure mapping and temperature estimation. The SCMN is also shown to have broad applications in humanoid robotics, new prosthetics, human-machine interfaces, and health-monitoring technologies. The human somatosensory system converts environmental stimuli into electrical impulses through various sensory receptors and neural pathways, enabling sensations of touch, heat/cold, and pain. Mechanosensation electronics (e-skin) mimic this system by detecting and quantifying various stimuli in the ambient environment. E-skin has attracted significant attention for its revolutionary applications in robotics, prosthetics, and health-monitoring technologies. The ability to sense multiple stimuli is an ultimate goal for e-skin systems, but previous reports have mainly focused on single or dual sensory capabilities. The SCMN overcomes this limitation by integrating multiple sensor units into a single network, enabling simultaneous detection and high selectivity of multi-complex stimuli from the ambient environment. The SCMN is composed of 100 sensory nodes connected by meandering wires, allowing for high flexibility and stretchability. The SCMN is tested for its stretchability and expandability, showing excellent performance under various conditions. The SCMN is also demonstrated for temperature sensing, in-plane strain sensing, humidity sensing, light sensing, magnetic field sensing, pressure and proximity sensing, and simultaneous multi-stimulus sensing. The SCMN is shown to have adjustable sensing ranges and large-area expandability, making it suitable for high-density 3D integration schemes. The SCMN is also demonstrated in a personalized intelligent prosthetic hand that can perform real-time spatial pressure mapping and temperature estimation. The SCMN is shown to have broad applications in humanoid robotics, new prosthetics, human-machine interfaces, and health-monitoring technologies. The SCMN is a significant advancement in mechanosensation electronics towards the Internet of 'actions' (IoA), which is expected to revolutionize healthcare, medical science, and robotics.