This review discusses the photoprotective role of carotenoid pigments in skin protection against ultraviolet (UVR) radiation. Carotenoids, natural pigments found in plants and some animals, have antioxidant and anti-inflammatory properties that help protect the skin from photodamage caused by UVR. They act as photoprotectors, reducing oxidative stress and DNA damage, and are used in both topical and systemic forms. Recent studies highlight the effectiveness of carotenoids in preventing skin cancer, photoaging, and other UV-induced skin conditions. The review also examines the use of nanoformulations, such as lipid nanoparticles, nanoemulsions, liposomes, and micelles, to enhance the bioavailability and stability of carotenoids as natural sun protection agents. The photoprotective effects of carotenoids are discussed in the context of their ability to quench reactive oxygen species (ROS), including singlet oxygen, and their role in reducing oxidative stress and inflammation. The review emphasizes the importance of carotenoids in skin protection, particularly in the context of UVR exposure, and highlights the potential of carotenoids as a natural alternative to synthetic sunscreens. The study also discusses the effects of various types of radiation, including ultraviolet (UVR), infrared (IR), and visible light (VL), on skin damage and the mechanisms by which carotenoids mitigate these effects. The review concludes that carotenoids, particularly lycopene and astaxanthin, have significant photoprotective potential and may be used as effective natural sun protection agents.This review discusses the photoprotective role of carotenoid pigments in skin protection against ultraviolet (UVR) radiation. Carotenoids, natural pigments found in plants and some animals, have antioxidant and anti-inflammatory properties that help protect the skin from photodamage caused by UVR. They act as photoprotectors, reducing oxidative stress and DNA damage, and are used in both topical and systemic forms. Recent studies highlight the effectiveness of carotenoids in preventing skin cancer, photoaging, and other UV-induced skin conditions. The review also examines the use of nanoformulations, such as lipid nanoparticles, nanoemulsions, liposomes, and micelles, to enhance the bioavailability and stability of carotenoids as natural sun protection agents. The photoprotective effects of carotenoids are discussed in the context of their ability to quench reactive oxygen species (ROS), including singlet oxygen, and their role in reducing oxidative stress and inflammation. The review emphasizes the importance of carotenoids in skin protection, particularly in the context of UVR exposure, and highlights the potential of carotenoids as a natural alternative to synthetic sunscreens. The study also discusses the effects of various types of radiation, including ultraviolet (UVR), infrared (IR), and visible light (VL), on skin damage and the mechanisms by which carotenoids mitigate these effects. The review concludes that carotenoids, particularly lycopene and astaxanthin, have significant photoprotective potential and may be used as effective natural sun protection agents.