The article provides an updated overview of skin wound healing, focusing on the main phases: inflammation, proliferation, epithelialization, angiogenesis, remodeling, and scarring. It highlights the role of macrophages in the inflammatory phase and the different mechanisms of epithelialization, such as leapfrogging, lamellipodial crawling, shuffling, and the stem cell niche. The article emphasizes the importance of neovascularization in wound healing and the functions of pericytes. It also discusses the challenges and potential treatments for scarring, tissue engineering, and the application of plasma in wound healing. Despite advancements, many underlying pathophysiological processes remain unknown, and further research is needed to enhance wound healing therapies.The article provides an updated overview of skin wound healing, focusing on the main phases: inflammation, proliferation, epithelialization, angiogenesis, remodeling, and scarring. It highlights the role of macrophages in the inflammatory phase and the different mechanisms of epithelialization, such as leapfrogging, lamellipodial crawling, shuffling, and the stem cell niche. The article emphasizes the importance of neovascularization in wound healing and the functions of pericytes. It also discusses the challenges and potential treatments for scarring, tissue engineering, and the application of plasma in wound healing. Despite advancements, many underlying pathophysiological processes remain unknown, and further research is needed to enhance wound healing therapies.