This article reviews the photoprotective effects of natural polyphenols, such as green tea polyphenols, grape seed proanthocyanidins, resveratrol, silymarin, and genistein, on UV-induced skin inflammation, oxidative stress, and DNA damage. These polyphenols have been shown to inhibit UV-induced skin diseases and cancers through various mechanisms, including anti-inflammatory, antioxidant, and DNA repair activities. The review highlights the protective effects of these polyphenols in animal models and human studies, emphasizing their potential as chemopreventive agents. The mechanisms of action include sunscreen effects, anti-inflammatory responses, and DNA repair pathways. The article also discusses the bioavailability and metabolism of polyphenols, suggesting that routine consumption or topical application may provide efficient protection against the harmful effects of solar ultraviolet radiation.This article reviews the photoprotective effects of natural polyphenols, such as green tea polyphenols, grape seed proanthocyanidins, resveratrol, silymarin, and genistein, on UV-induced skin inflammation, oxidative stress, and DNA damage. These polyphenols have been shown to inhibit UV-induced skin diseases and cancers through various mechanisms, including anti-inflammatory, antioxidant, and DNA repair activities. The review highlights the protective effects of these polyphenols in animal models and human studies, emphasizing their potential as chemopreventive agents. The mechanisms of action include sunscreen effects, anti-inflammatory responses, and DNA repair pathways. The article also discusses the bioavailability and metabolism of polyphenols, suggesting that routine consumption or topical application may provide efficient protection against the harmful effects of solar ultraviolet radiation.