2024 | Pauline Dodet, Marion Houot, Smaranda Leu-Semenescu, Jean-Christophe Corvol, Stéphane Lehéricy, Graziella Mangone, Marie Vidalhie, Emmanuel Roze and Isabelle Arnulf
Sleep disorders are common and often combined in early-stage Parkinson's disease (PD). A study of 162 PD patients and 58 healthy controls found that 71% of PD patients had at least one sleep disorder, with insomnia (41%), definite REM sleep behavior disorder (RBD, 25%), excessive daytime sleepiness (EDS, 25%), and restless legs syndrome (RLS, 16%) being the most frequent. These disorders were more common in PD patients than in controls, while sleep-disordered breathing (SDB) was rare and similar in both groups. Half of the patients had multiple sleep disorders, with insomnia being the most common. Sleep disturbances were associated with factors such as female gender, shorter sleep time, RLS, dysautonomia, and advanced age. Insomnia was not linked to motor or psychological symptoms, while RBD was associated with dysautonomia and advanced age. EDS was linked to psychiatric and motor symptoms and the sedative effects of dopamine agonists. The study highlights that sleep disturbances are frequent and complex in early PD, with organic rather than psychological determinants. The findings suggest that sleep disorders should be considered as an early and important aspect of PD, requiring comprehensive evaluation and management. The study also emphasizes the importance of sleep recording and expert evaluation for complex cases. The results indicate that sleep disorders in early PD may influence long-term motor and cognitive outcomes, underscoring the need for early detection and intervention.Sleep disorders are common and often combined in early-stage Parkinson's disease (PD). A study of 162 PD patients and 58 healthy controls found that 71% of PD patients had at least one sleep disorder, with insomnia (41%), definite REM sleep behavior disorder (RBD, 25%), excessive daytime sleepiness (EDS, 25%), and restless legs syndrome (RLS, 16%) being the most frequent. These disorders were more common in PD patients than in controls, while sleep-disordered breathing (SDB) was rare and similar in both groups. Half of the patients had multiple sleep disorders, with insomnia being the most common. Sleep disturbances were associated with factors such as female gender, shorter sleep time, RLS, dysautonomia, and advanced age. Insomnia was not linked to motor or psychological symptoms, while RBD was associated with dysautonomia and advanced age. EDS was linked to psychiatric and motor symptoms and the sedative effects of dopamine agonists. The study highlights that sleep disturbances are frequent and complex in early PD, with organic rather than psychological determinants. The findings suggest that sleep disorders should be considered as an early and important aspect of PD, requiring comprehensive evaluation and management. The study also emphasizes the importance of sleep recording and expert evaluation for complex cases. The results indicate that sleep disorders in early PD may influence long-term motor and cognitive outcomes, underscoring the need for early detection and intervention.