The topic of patient safety has gained increasing importance in recent decades, especially since the 1999 report "To Err is Human" by the American Institute of Medicine (IOM). Studies show that medical errors are more frequent than previously thought, with medication errors, mix-ups, and communication errors being common. Before the pandemic, most safety projects were analog, but since 2020, the focus has shifted to digital solutions, including artificial intelligence (AI). The term "Smart Hospital" is often associated with digital solutions, but it actually refers to the combination of digitalization and adaptation of traditional workflows. To illustrate the integration of digitalization and AI, the risk of medication errors is discussed. Medication errors are a central problem, with overdosing, underdosing, incorrect or missing medications being frequent. Globally, about 7,000 people die annually due to unreadable handwriting. Digital solutions can significantly reduce error rates in the medication process. A research project by the Medical University of Graz investigates how AI can contribute to optimizing the medication process. Digital systems offer benefits such as error reduction and staff relief. Technological innovations bring both opportunities and challenges, with acceptance often increasing after initial resistance. Through digitalization and AI, patient and staff safety can be enhanced. It is important to develop and implement the right tools at the right process step. Patient safety has become increasingly important in recent decades. Since the publication of the "To Err is Human" report by the American Institute of Medicine (IOM) in 1999, topics such as medical errors, patient safety, and treatment quality have gained increasing attention. A further study from the US showed that the error rate is much higher than initially assumed. The most frequent errors are medication errors, mix-ups, information and communication errors, and medical errors. Many efforts have been made to improve patient safety, such as the creation of checklists like the WHO Surgical Safety Checklist, the development of scores, or attention to readability in handwritten documents. Before the pandemic, most safety projects were analog. In recent years, projects aimed at improving patient safety have mainly focused on digital and AI-enhanced aspects. The change has been so rapid that it is difficult to keep up. In the following, the aspects of a Smart Hospital are briefly presented and its impact on patient safety is discussed. The contribution is based on the long-term expertise of the Medical University of Graz, Research Unit for Safety and Sustainability in Health Care, and the LKH-University Clinic in Graz in the field of implementation and sustainability research in patient safety. What does "Smart Hospital" actually mean? The first association is with digitalization and the possibilities that AI brings. In the healthcare sector, there were already many digitalization projects in the early 2000s, and its beginnings are at least associated with the "electronic health record" in Austria. The digitalization progress, which now takes place in recent years,The topic of patient safety has gained increasing importance in recent decades, especially since the 1999 report "To Err is Human" by the American Institute of Medicine (IOM). Studies show that medical errors are more frequent than previously thought, with medication errors, mix-ups, and communication errors being common. Before the pandemic, most safety projects were analog, but since 2020, the focus has shifted to digital solutions, including artificial intelligence (AI). The term "Smart Hospital" is often associated with digital solutions, but it actually refers to the combination of digitalization and adaptation of traditional workflows. To illustrate the integration of digitalization and AI, the risk of medication errors is discussed. Medication errors are a central problem, with overdosing, underdosing, incorrect or missing medications being frequent. Globally, about 7,000 people die annually due to unreadable handwriting. Digital solutions can significantly reduce error rates in the medication process. A research project by the Medical University of Graz investigates how AI can contribute to optimizing the medication process. Digital systems offer benefits such as error reduction and staff relief. Technological innovations bring both opportunities and challenges, with acceptance often increasing after initial resistance. Through digitalization and AI, patient and staff safety can be enhanced. It is important to develop and implement the right tools at the right process step. Patient safety has become increasingly important in recent decades. Since the publication of the "To Err is Human" report by the American Institute of Medicine (IOM) in 1999, topics such as medical errors, patient safety, and treatment quality have gained increasing attention. A further study from the US showed that the error rate is much higher than initially assumed. The most frequent errors are medication errors, mix-ups, information and communication errors, and medical errors. Many efforts have been made to improve patient safety, such as the creation of checklists like the WHO Surgical Safety Checklist, the development of scores, or attention to readability in handwritten documents. Before the pandemic, most safety projects were analog. In recent years, projects aimed at improving patient safety have mainly focused on digital and AI-enhanced aspects. The change has been so rapid that it is difficult to keep up. In the following, the aspects of a Smart Hospital are briefly presented and its impact on patient safety is discussed. The contribution is based on the long-term expertise of the Medical University of Graz, Research Unit for Safety and Sustainability in Health Care, and the LKH-University Clinic in Graz in the field of implementation and sustainability research in patient safety. What does "Smart Hospital" actually mean? The first association is with digitalization and the possibilities that AI brings. In the healthcare sector, there were already many digitalization projects in the early 2000s, and its beginnings are at least associated with the "electronic health record" in Austria. The digitalization progress, which now takes place in recent years,