The article presents an organic cage-based humidity sensor with exceptional humidity responsiveness, which can be used to develop advanced touchless human-machine interaction (HMI) systems. The sensor, featuring a 3D crystal structure and abundant water-absorbing functional groups, exhibits ultrafast response/recovery times (1 s/3 s) and remarkable stability (over 800 cycles) across a wide range of relative humidity (RH) changes from 11% to 95%. The sensor's performance is attributed to its self-assembled 3D pore network and H-bonding anchors, which facilitate efficient water diffusion and transport. The study compares the sensor's performance with other materials, demonstrating its superior sensitivity and stability. The sensor has been successfully applied in touchless control screens and password managers, showcasing its potential in touchless HMI applications. The research highlights the promising role of molecularly porous materials in touchless HMI, offering a new approach to seamless and hygienic human-machine interaction.The article presents an organic cage-based humidity sensor with exceptional humidity responsiveness, which can be used to develop advanced touchless human-machine interaction (HMI) systems. The sensor, featuring a 3D crystal structure and abundant water-absorbing functional groups, exhibits ultrafast response/recovery times (1 s/3 s) and remarkable stability (over 800 cycles) across a wide range of relative humidity (RH) changes from 11% to 95%. The sensor's performance is attributed to its self-assembled 3D pore network and H-bonding anchors, which facilitate efficient water diffusion and transport. The study compares the sensor's performance with other materials, demonstrating its superior sensitivity and stability. The sensor has been successfully applied in touchless control screens and password managers, showcasing its potential in touchless HMI applications. The research highlights the promising role of molecularly porous materials in touchless HMI, offering a new approach to seamless and hygienic human-machine interaction.