This systematic review examines social media misinformation about COVID-19 vaccination during pregnancy, its spread, and proposed solutions. The study identified three eligible articles from databases Embase and Medline, covering the period from December 2019 to February 8, 2023. Misinformation primarily focused on vaccine safety, infertility, and harmful side effects. The rapid dissemination of misinformation was attributed to lack of social media monitoring, anti-vaccination messages, and insufficient accurate information. Solutions suggested include integrating COVID-19 vaccination discussions into antenatal care, increasing social media presence by healthcare providers and public health/government entities, and addressing population-specific concerns in culturally relevant ways. The review highlights the need for increased information from reputable sources to combat misinformation and improve vaccine uptake among pregnant women.This systematic review examines social media misinformation about COVID-19 vaccination during pregnancy, its spread, and proposed solutions. The study identified three eligible articles from databases Embase and Medline, covering the period from December 2019 to February 8, 2023. Misinformation primarily focused on vaccine safety, infertility, and harmful side effects. The rapid dissemination of misinformation was attributed to lack of social media monitoring, anti-vaccination messages, and insufficient accurate information. Solutions suggested include integrating COVID-19 vaccination discussions into antenatal care, increasing social media presence by healthcare providers and public health/government entities, and addressing population-specific concerns in culturally relevant ways. The review highlights the need for increased information from reputable sources to combat misinformation and improve vaccine uptake among pregnant women.