This study explores the mediating role of perceived stress in the relationship between social support and mental health outcomes among Filipino adults during the COVID-19 pandemic. Drawing from Lazarus and Folkman's stress and coping theory, the study examines how social support from family, significant others, and friends influences perceived stress, which in turn affects positive affect, anxiety, and depression. A cross-sectional survey was conducted online with 426 participants. The results show that perceived stress significantly mediates the relationship between family and significant other support and positive affect, anxiety, and depression. Family and significant other support reduce perceived stress, increasing positive affect and decreasing anxiety and depression. However, perceived stress does not mediate the relationship between friend support and mental health outcomes. The study highlights the importance of social support in reducing perceived stress and its implications for clinical interventions and future research.This study explores the mediating role of perceived stress in the relationship between social support and mental health outcomes among Filipino adults during the COVID-19 pandemic. Drawing from Lazarus and Folkman's stress and coping theory, the study examines how social support from family, significant others, and friends influences perceived stress, which in turn affects positive affect, anxiety, and depression. A cross-sectional survey was conducted online with 426 participants. The results show that perceived stress significantly mediates the relationship between family and significant other support and positive affect, anxiety, and depression. Family and significant other support reduce perceived stress, increasing positive affect and decreasing anxiety and depression. However, perceived stress does not mediate the relationship between friend support and mental health outcomes. The study highlights the importance of social support in reducing perceived stress and its implications for clinical interventions and future research.