The NCCN Guidelines for Soft Tissue Sarcoma (STS) provide comprehensive recommendations for the diagnosis, staging, and treatment of STS in adults. STS are rare tumors originating from mesenchymal cells, including fat, muscle, nerves, blood vessels, and connective tissues. The guidelines emphasize the importance of a multidisciplinary approach and highlight the need for high-quality imaging, including MRI and CT, to accurately stage the disease. Treatment options include surgery, radiation therapy, and systemic therapy, with recommendations tailored to the specific subtype and stage of STS. The guidelines also address the role of preoperative and postoperative radiation therapy, limb-sparing surgery, and the use of advanced technologies such as intensity-modulated radiation therapy (IMRT) and proton therapy. Systemic therapies, including chemotherapy and targeted agents, are discussed for their efficacy and safety in various STS subtypes. The guidelines aim to improve patient outcomes and reduce recurrence rates by providing evidence-based recommendations.The NCCN Guidelines for Soft Tissue Sarcoma (STS) provide comprehensive recommendations for the diagnosis, staging, and treatment of STS in adults. STS are rare tumors originating from mesenchymal cells, including fat, muscle, nerves, blood vessels, and connective tissues. The guidelines emphasize the importance of a multidisciplinary approach and highlight the need for high-quality imaging, including MRI and CT, to accurately stage the disease. Treatment options include surgery, radiation therapy, and systemic therapy, with recommendations tailored to the specific subtype and stage of STS. The guidelines also address the role of preoperative and postoperative radiation therapy, limb-sparing surgery, and the use of advanced technologies such as intensity-modulated radiation therapy (IMRT) and proton therapy. Systemic therapies, including chemotherapy and targeted agents, are discussed for their efficacy and safety in various STS subtypes. The guidelines aim to improve patient outcomes and reduce recurrence rates by providing evidence-based recommendations.