The NCCN Soft Tissue Sarcoma (STS) Clinical Practice Guidelines, Version 2.2018, provide recommendations for the diagnosis, staging, and treatment of STS in adults. STS is a rare group of tumors arising from mesenchymal cells, with common sites including soft tissues, bones, and other connective tissues. The guidelines emphasize a multidisciplinary approach involving oncologists, surgeons, radiologists, and pathologists. They cover various subtypes of STS, including undifferentiated pleomorphic sarcoma, gastrointestinal stromal tumors, liposarcoma, and leiomyosarcoma. The guidelines recommend imaging, biopsy, and staging for accurate diagnosis and treatment planning. They also address the importance of clinical trials in cancer treatment and provide evidence-based recommendations for treatment options, including surgery, radiation therapy, and systemic therapy. The guidelines are categorized into different levels of evidence, with Category 2A being the most commonly recommended. The guidelines also include information on follow-up, rehabilitation, and management of recurrence. The NCCN guidelines are intended to be used in conjunction with other NCCN guidelines and are available online for further reference. The guidelines are reviewed and updated regularly to ensure they reflect the latest medical knowledge and best practices in the treatment of STS.The NCCN Soft Tissue Sarcoma (STS) Clinical Practice Guidelines, Version 2.2018, provide recommendations for the diagnosis, staging, and treatment of STS in adults. STS is a rare group of tumors arising from mesenchymal cells, with common sites including soft tissues, bones, and other connective tissues. The guidelines emphasize a multidisciplinary approach involving oncologists, surgeons, radiologists, and pathologists. They cover various subtypes of STS, including undifferentiated pleomorphic sarcoma, gastrointestinal stromal tumors, liposarcoma, and leiomyosarcoma. The guidelines recommend imaging, biopsy, and staging for accurate diagnosis and treatment planning. They also address the importance of clinical trials in cancer treatment and provide evidence-based recommendations for treatment options, including surgery, radiation therapy, and systemic therapy. The guidelines are categorized into different levels of evidence, with Category 2A being the most commonly recommended. The guidelines also include information on follow-up, rehabilitation, and management of recurrence. The NCCN guidelines are intended to be used in conjunction with other NCCN guidelines and are available online for further reference. The guidelines are reviewed and updated regularly to ensure they reflect the latest medical knowledge and best practices in the treatment of STS.