Soil salinization is a critical threat to agriculture and food security, affecting soil structure, fertility, plant growth, and microorganisms. It is caused by natural processes such as dry climates, high evaporation rates, and human factors like inappropriate irrigation practices and excessive fertilizer use. The growing extremity of climate change, with prolonged drought conditions, exacerbates this issue. Nature-based solutions (NBS) combined with precision or conservation agriculture offer sustainable responses, revitalizing ecosystem services. However, NBS alone may not be sufficient to combat hunger in vulnerable regions and achieve the Sustainable Development Goal (SDG2) of Zero Hunger. Therefore, the paper explores the combination of NBS with salt-tolerant crops based on bioengineering. The introduction highlights the importance of sustainable food production systems to ensure peace and prosperity, emphasizing the need to address soil salinization through sustainable and resilient agricultural practices. The paper discusses the challenges and limitations of implementing NBS, such as land tenure issues, insufficient local knowledge, and upfront costs. It also emphasizes the importance of understanding regional specificities for successful adoption. The paper explores various NBS, including natural barriers like mangroves, salt-marshes, and seagrass meadows, which provide sustainable and effective mitigation strategies. Wetland restoration is another compelling NBS that can help tackle salinity intrusion in deltas by holding and filtering water, recharging groundwater, and resisting saline water infiltration. Buffer zones along canals and ditches can also mitigate saltwater intrusion by acting as barriers between freshwater aquifers and saline water bodies. The paper also discusses innovative agricultural practices, such as rice-prawn rotational farming in the Mekong Delta, which adapts to saline conditions and supports livelihoods. Other strategies include straw incorporation, microbial-based solutions, organic fertilizers, crop rotation, and water storage and irrigation techniques. Bioengineering in selecting and creating salt-tolerant crops is proposed as a valid alternative, especially for large-scale agricultural systems. The combination of NBS and bioengineering is recommended to fully achieve SDG2 while ensuring environmental sustainability. In conclusion, the paper emphasizes the importance of combining NBS and bioengineering to mitigate soil salinization in agriculture, ensuring sustainable and resilient agricultural practices.Soil salinization is a critical threat to agriculture and food security, affecting soil structure, fertility, plant growth, and microorganisms. It is caused by natural processes such as dry climates, high evaporation rates, and human factors like inappropriate irrigation practices and excessive fertilizer use. The growing extremity of climate change, with prolonged drought conditions, exacerbates this issue. Nature-based solutions (NBS) combined with precision or conservation agriculture offer sustainable responses, revitalizing ecosystem services. However, NBS alone may not be sufficient to combat hunger in vulnerable regions and achieve the Sustainable Development Goal (SDG2) of Zero Hunger. Therefore, the paper explores the combination of NBS with salt-tolerant crops based on bioengineering. The introduction highlights the importance of sustainable food production systems to ensure peace and prosperity, emphasizing the need to address soil salinization through sustainable and resilient agricultural practices. The paper discusses the challenges and limitations of implementing NBS, such as land tenure issues, insufficient local knowledge, and upfront costs. It also emphasizes the importance of understanding regional specificities for successful adoption. The paper explores various NBS, including natural barriers like mangroves, salt-marshes, and seagrass meadows, which provide sustainable and effective mitigation strategies. Wetland restoration is another compelling NBS that can help tackle salinity intrusion in deltas by holding and filtering water, recharging groundwater, and resisting saline water infiltration. Buffer zones along canals and ditches can also mitigate saltwater intrusion by acting as barriers between freshwater aquifers and saline water bodies. The paper also discusses innovative agricultural practices, such as rice-prawn rotational farming in the Mekong Delta, which adapts to saline conditions and supports livelihoods. Other strategies include straw incorporation, microbial-based solutions, organic fertilizers, crop rotation, and water storage and irrigation techniques. Bioengineering in selecting and creating salt-tolerant crops is proposed as a valid alternative, especially for large-scale agricultural systems. The combination of NBS and bioengineering is recommended to fully achieve SDG2 while ensuring environmental sustainability. In conclusion, the paper emphasizes the importance of combining NBS and bioengineering to mitigate soil salinization in agriculture, ensuring sustainable and resilient agricultural practices.