Alzheimer's disease (AD) is a progressive neurodegenerative disorder associated with aging, characterized by memory loss, cognitive decline, and behavioral changes. Despite extensive research, no cure exists, and current treatments have limited efficacy. Ayurvedic medicinal herbs show promise in AD treatment, with compounds like lignans, flavonoids, tannins, polyphenols, triterpenes, sterols, and alkaloids exhibiting anti-inflammatory, anti-amyloidogenic, anticholinesterase, hypolipidemic, and antioxidant effects. These compounds, found in plants such as Ginkgo biloba, Bacopa monnieri, Salvia officinalis, Curcuma longa, Rosmarinus officinalis, Melissa officinalis, Glycyrrhiza glabra, Galanthus nivalis, Huperzia serrata, Lepidium meyenii Walp., Centella asiatica, and Tinospora cordifolia, have demonstrated neuroprotective, anti-inflammatory, and cognitive-enhancing properties. These plants contain bioactive compounds that may help mitigate oxidative stress, reduce inflammation, and inhibit amyloid-beta aggregation, potentially slowing AD progression. While clinical trials are needed to validate these findings, Ayurvedic herbs offer a promising avenue for developing novel therapies for AD. The review highlights the phytochemical and ethnomedicinal potential of these plants, emphasizing their role in addressing the growing burden of Alzheimer's disease.Alzheimer's disease (AD) is a progressive neurodegenerative disorder associated with aging, characterized by memory loss, cognitive decline, and behavioral changes. Despite extensive research, no cure exists, and current treatments have limited efficacy. Ayurvedic medicinal herbs show promise in AD treatment, with compounds like lignans, flavonoids, tannins, polyphenols, triterpenes, sterols, and alkaloids exhibiting anti-inflammatory, anti-amyloidogenic, anticholinesterase, hypolipidemic, and antioxidant effects. These compounds, found in plants such as Ginkgo biloba, Bacopa monnieri, Salvia officinalis, Curcuma longa, Rosmarinus officinalis, Melissa officinalis, Glycyrrhiza glabra, Galanthus nivalis, Huperzia serrata, Lepidium meyenii Walp., Centella asiatica, and Tinospora cordifolia, have demonstrated neuroprotective, anti-inflammatory, and cognitive-enhancing properties. These plants contain bioactive compounds that may help mitigate oxidative stress, reduce inflammation, and inhibit amyloid-beta aggregation, potentially slowing AD progression. While clinical trials are needed to validate these findings, Ayurvedic herbs offer a promising avenue for developing novel therapies for AD. The review highlights the phytochemical and ethnomedicinal potential of these plants, emphasizing their role in addressing the growing burden of Alzheimer's disease.