Spatial neglect is a neurological syndrome caused by damage to the right hemisphere, particularly in the ventral fronto-parietal cortex. It is characterized by a bias in spatial attention and salience mapped in an egocentric reference frame, leading to impaired attention and reporting of stimuli on the contralesional side. The syndrome involves deficits in spatial attention, salience, and non-spatial functions such as arousal, reorienting, and detection. These deficits are linked to dysfunction in distributed cortical networks, particularly the dorsal frontal-parietal network that controls spatial attention and eye movements. The right hemisphere dominance of neglect is due to the anatomical and functional interactions between ventral and dorsal attention networks. The ventral regions, which are often damaged in neglect, interact with the dorsal network, leading to abnormalities in task-evoked activity and functional connectivity. The core spatial deficit in neglect is associated with an egocentric bias in attention and salience, while non-spatial deficits involve arousal and reorienting. The right hemisphere dominance of neglect is explained by the lateralization of these non-spatial functions and their interaction with the dorsal network. Neuroimaging studies have shown that the dorsal fronto-parietal network is involved in spatial attention, while the ventral regions are associated with non-spatial functions. The abnormalities in the dorsal network are linked to inter-hemispheric interactions and response imbalances. The right hemisphere dominance of neglect is further supported by the lateralization of non-spatial functions such as reorienting, target detection, and arousal. The ventral regions damaged in neglect are involved in these non-spatial functions, and their dysfunction contributes to the spatial neglect syndrome. The right hemisphere dominance of neglect is a complex phenomenon that involves the interaction between ventral and dorsal attention networks, as well as the lateralization of non-spatial functions. The physiological mechanisms underlying spatial neglect are still not fully understood, but recent studies suggest that the dysfunction of these networks is a key factor in the syndrome.Spatial neglect is a neurological syndrome caused by damage to the right hemisphere, particularly in the ventral fronto-parietal cortex. It is characterized by a bias in spatial attention and salience mapped in an egocentric reference frame, leading to impaired attention and reporting of stimuli on the contralesional side. The syndrome involves deficits in spatial attention, salience, and non-spatial functions such as arousal, reorienting, and detection. These deficits are linked to dysfunction in distributed cortical networks, particularly the dorsal frontal-parietal network that controls spatial attention and eye movements. The right hemisphere dominance of neglect is due to the anatomical and functional interactions between ventral and dorsal attention networks. The ventral regions, which are often damaged in neglect, interact with the dorsal network, leading to abnormalities in task-evoked activity and functional connectivity. The core spatial deficit in neglect is associated with an egocentric bias in attention and salience, while non-spatial deficits involve arousal and reorienting. The right hemisphere dominance of neglect is explained by the lateralization of these non-spatial functions and their interaction with the dorsal network. Neuroimaging studies have shown that the dorsal fronto-parietal network is involved in spatial attention, while the ventral regions are associated with non-spatial functions. The abnormalities in the dorsal network are linked to inter-hemispheric interactions and response imbalances. The right hemisphere dominance of neglect is further supported by the lateralization of non-spatial functions such as reorienting, target detection, and arousal. The ventral regions damaged in neglect are involved in these non-spatial functions, and their dysfunction contributes to the spatial neglect syndrome. The right hemisphere dominance of neglect is a complex phenomenon that involves the interaction between ventral and dorsal attention networks, as well as the lateralization of non-spatial functions. The physiological mechanisms underlying spatial neglect are still not fully understood, but recent studies suggest that the dysfunction of these networks is a key factor in the syndrome.