09 March 2024 | Nima Mirkhani, Michael G. Christiansen, Tinotenda Gwisai, Stefano Menghini & Simone Schuerle
This study presents a method for spatially selective delivery of living magnetic microrobots using torque-focusing, combining rotating magnetic fields (RMFs) with magnetostatic selection fields. The approach enables precise control of torque density to target specific regions, reducing off-target actuation. The research demonstrates that this strategy can enhance the accumulation of intravenously injected bacteria in tumors compared to non-actuated or globally actuated groups. The method is validated in vitro and in vivo, showing improved tumor colonization and reduced off-target effects. The system includes a mouse-scale torque-focusing apparatus with an external array of permanent magnets, an internal RMF generator, and DC coils to maneuver the field-free point. The results indicate that torque-based actuation, combined with spatial targeting, offers a promising approach for targeted drug delivery and bacterial cancer therapy. The study highlights the advantages of torque-based actuation in overcoming physiological barriers and enhancing tumor penetration, while minimizing off-target effects. The findings suggest that this method could improve the efficiency of therapeutic delivery in cancer treatment.This study presents a method for spatially selective delivery of living magnetic microrobots using torque-focusing, combining rotating magnetic fields (RMFs) with magnetostatic selection fields. The approach enables precise control of torque density to target specific regions, reducing off-target actuation. The research demonstrates that this strategy can enhance the accumulation of intravenously injected bacteria in tumors compared to non-actuated or globally actuated groups. The method is validated in vitro and in vivo, showing improved tumor colonization and reduced off-target effects. The system includes a mouse-scale torque-focusing apparatus with an external array of permanent magnets, an internal RMF generator, and DC coils to maneuver the field-free point. The results indicate that torque-based actuation, combined with spatial targeting, offers a promising approach for targeted drug delivery and bacterial cancer therapy. The study highlights the advantages of torque-based actuation in overcoming physiological barriers and enhancing tumor penetration, while minimizing off-target effects. The findings suggest that this method could improve the efficiency of therapeutic delivery in cancer treatment.