A study published in JAMA (2011) analyzed cancer risk among U.S. solid organ transplant recipients, finding elevated cancer risk compared to the general population. The study used data from the U.S. Scientific Registry of Transplant Recipients (SRTR) and 13 state cancer registries, covering 175,732 transplants between 1987 and 2008. Overall cancer risk was 2.10 times higher (SIR 2.10, 95%CI 2.06–2.14) than in the general population, with excess absolute risk (EAR) of 719.3 per 100,000 person-years. The most elevated risks were for non-Hodgkin lymphoma (SIR 7.54), lung cancer (SIR 1.97), liver cancer (SIR 11.56), and kidney cancer (SIR 4.65). Lung cancer risk was highest in lung recipients (SIR 6.13), while liver cancer risk was only elevated in liver recipients (SIR 43.83). Kidney cancer risk was elevated in kidney, liver, and heart recipients. The study found that cancer risk varied by transplanted organ, with some cancers more prevalent in specific recipient groups. The findings highlight the increased risk of both infection-related and unrelated cancers among transplant recipients, emphasizing the need for further research into cancer prevention and early detection in this population.A study published in JAMA (2011) analyzed cancer risk among U.S. solid organ transplant recipients, finding elevated cancer risk compared to the general population. The study used data from the U.S. Scientific Registry of Transplant Recipients (SRTR) and 13 state cancer registries, covering 175,732 transplants between 1987 and 2008. Overall cancer risk was 2.10 times higher (SIR 2.10, 95%CI 2.06–2.14) than in the general population, with excess absolute risk (EAR) of 719.3 per 100,000 person-years. The most elevated risks were for non-Hodgkin lymphoma (SIR 7.54), lung cancer (SIR 1.97), liver cancer (SIR 11.56), and kidney cancer (SIR 4.65). Lung cancer risk was highest in lung recipients (SIR 6.13), while liver cancer risk was only elevated in liver recipients (SIR 43.83). Kidney cancer risk was elevated in kidney, liver, and heart recipients. The study found that cancer risk varied by transplanted organ, with some cancers more prevalent in specific recipient groups. The findings highlight the increased risk of both infection-related and unrelated cancers among transplant recipients, emphasizing the need for further research into cancer prevention and early detection in this population.