Sphingolipids, including ceramide, sphingosine-1-phosphate (S1P), and ceramide-1-phosphate (C1P), are signaling molecules that play crucial roles in regulating cellular processes such as cell growth, survival, immune cell trafficking, and vascular integrity. Recent advancements in sphingolipidomics and animal models have provided significant insights into the molecular mechanisms of action of these metabolites and their roles in chronic inflammation. The discovery of FTY720, a sphingosine analogue, has opened new therapeutic avenues for inflammatory disorders like multiple sclerosis. This review focuses on the functions of ceramide, C1P, and S1P, and their roles in inflammation. It highlights how these bioactive sphingolipids contribute to various inflammatory diseases, including asthma, inflammatory bowel disease, and autoimmune disorders. The review also discusses the potential of sphingolipid-based therapies and the challenges in understanding their complex mechanisms.Sphingolipids, including ceramide, sphingosine-1-phosphate (S1P), and ceramide-1-phosphate (C1P), are signaling molecules that play crucial roles in regulating cellular processes such as cell growth, survival, immune cell trafficking, and vascular integrity. Recent advancements in sphingolipidomics and animal models have provided significant insights into the molecular mechanisms of action of these metabolites and their roles in chronic inflammation. The discovery of FTY720, a sphingosine analogue, has opened new therapeutic avenues for inflammatory disorders like multiple sclerosis. This review focuses on the functions of ceramide, C1P, and S1P, and their roles in inflammation. It highlights how these bioactive sphingolipids contribute to various inflammatory diseases, including asthma, inflammatory bowel disease, and autoimmune disorders. The review also discusses the potential of sphingolipid-based therapies and the challenges in understanding their complex mechanisms.