The paper by Dr. Dimitrios Buhalis explores the strategic use of information technologies (ITs) in the tourism industry. ITs are identified as pivotal tools that can enhance competitiveness, improve productivity, and facilitate innovative management practices. The author emphasizes that while ITs offer numerous opportunities, they also pose challenges, and organizations must adopt them strategically to remain competitive. The paper outlines the evolution of ITs in tourism, from Computer Reservation Systems (CRSs) to Global Distribution Systems (GDSs) and the Internet, each contributing to the industry's transformation. It highlights the importance of ITs in enhancing consumer interaction, improving service quality, and enabling globalized marketing. The paper also discusses the impact of ITs on intra-organizational and inter-organizational functions, consumer behavior, and the future of travel intermediation. A multi-dimensional strategic framework is proposed to guide the effective use of ITs in tourism, emphasizing the need for continuous business process re-engineering, commitment from top management, and training to ensure ITs are utilized effectively. The conclusion underscores that the successful integration of ITs will be crucial for the future success of tourism organizations and destinations.The paper by Dr. Dimitrios Buhalis explores the strategic use of information technologies (ITs) in the tourism industry. ITs are identified as pivotal tools that can enhance competitiveness, improve productivity, and facilitate innovative management practices. The author emphasizes that while ITs offer numerous opportunities, they also pose challenges, and organizations must adopt them strategically to remain competitive. The paper outlines the evolution of ITs in tourism, from Computer Reservation Systems (CRSs) to Global Distribution Systems (GDSs) and the Internet, each contributing to the industry's transformation. It highlights the importance of ITs in enhancing consumer interaction, improving service quality, and enabling globalized marketing. The paper also discusses the impact of ITs on intra-organizational and inter-organizational functions, consumer behavior, and the future of travel intermediation. A multi-dimensional strategic framework is proposed to guide the effective use of ITs in tourism, emphasizing the need for continuous business process re-engineering, commitment from top management, and training to ensure ITs are utilized effectively. The conclusion underscores that the successful integration of ITs will be crucial for the future success of tourism organizations and destinations.