A systematic review of strategies to address vaccine hesitancy was conducted, analyzing peer-reviewed and grey literature from 2007 to 2013. The review aimed to identify, describe, and assess the effectiveness of interventions to manage vaccine hesitancy across diverse global contexts. The majority of studies focused on influenza, HPV, and childhood vaccines in the Americas, while low- and middle-income regions focused on diphtheria, tetanus, pertussis, and polio. Most interventions were multi-component, with a focus on knowledge and awareness. The review found that multicomponent and dialogue-based interventions were most effective, though evidence was limited. Strategies such as social mobilization, mass media, communication training for healthcare workers, non-financial incentives, and reminder-recall interventions showed moderate effectiveness. However, many interventions had limited evidence, and their effectiveness varied by context and population. The review highlighted the need for tailored strategies that address specific concerns and contexts. While some interventions showed positive outcomes, others had limited impact. The review also noted that non-financial incentives and reminder-recall interventions had good quality evidence but were not universally effective. Overall, the review concluded that vaccine hesitancy is complex and requires comprehensive, context-specific approaches to address effectively.A systematic review of strategies to address vaccine hesitancy was conducted, analyzing peer-reviewed and grey literature from 2007 to 2013. The review aimed to identify, describe, and assess the effectiveness of interventions to manage vaccine hesitancy across diverse global contexts. The majority of studies focused on influenza, HPV, and childhood vaccines in the Americas, while low- and middle-income regions focused on diphtheria, tetanus, pertussis, and polio. Most interventions were multi-component, with a focus on knowledge and awareness. The review found that multicomponent and dialogue-based interventions were most effective, though evidence was limited. Strategies such as social mobilization, mass media, communication training for healthcare workers, non-financial incentives, and reminder-recall interventions showed moderate effectiveness. However, many interventions had limited evidence, and their effectiveness varied by context and population. The review highlighted the need for tailored strategies that address specific concerns and contexts. While some interventions showed positive outcomes, others had limited impact. The review also noted that non-financial incentives and reminder-recall interventions had good quality evidence but were not universally effective. Overall, the review concluded that vaccine hesitancy is complex and requires comprehensive, context-specific approaches to address effectively.