The article discusses strategies for multilocus linkage analysis in humans, emphasizing the increasing importance of DNA polymorphisms in constructing fine genetic maps. The authors investigate the efficiency of two-point and three-point linkage tests and develop the computer program LINKAGE to perform multilocus linkage analysis. They propose a method for location scores to efficiently detect linkage between a disease locus or new genetic marker and an established linkage group. The study highlights the benefits of multilocus analysis, such as increased precision in estimating genetic locations and reducing the problem of estimating multiple parameters to a single parameter under the assumption of no interference. An example using simulated pedigree data for Duchenne muscular dystrophy illustrates the method of location scores, showing its ability to provide more significant evidence of linkage compared to pairwise lod-scores. The authors advocate for the creation of a reference panel of families to facilitate the detection of polymorphisms and genetic analysis, emphasizing the potential for cooperative efforts in mapping the human genome.The article discusses strategies for multilocus linkage analysis in humans, emphasizing the increasing importance of DNA polymorphisms in constructing fine genetic maps. The authors investigate the efficiency of two-point and three-point linkage tests and develop the computer program LINKAGE to perform multilocus linkage analysis. They propose a method for location scores to efficiently detect linkage between a disease locus or new genetic marker and an established linkage group. The study highlights the benefits of multilocus analysis, such as increased precision in estimating genetic locations and reducing the problem of estimating multiple parameters to a single parameter under the assumption of no interference. An example using simulated pedigree data for Duchenne muscular dystrophy illustrates the method of location scores, showing its ability to provide more significant evidence of linkage compared to pairwise lod-scores. The authors advocate for the creation of a reference panel of families to facilitate the detection of polymorphisms and genetic analysis, emphasizing the potential for cooperative efforts in mapping the human genome.