The article discusses the concept of the general adaptation syndrome (GAS), introduced by Hans Selye, which integrates various physiological and pathological observations into a unified biological system. Selye highlights the importance of maintaining internal stability (homeostasis) and the body's response to stress, which includes three stages: alarm reaction, resistance, and exhaustion. Stressors can cause damage, but the body's defense mechanisms, including the nervous and hormonal systems, help to counteract this damage. The GAS concept suggests that all living organisms respond to stress in a similar manner, and that adaptability is a finite resource influenced by genetic factors. The article also explores the role of various hormones, such as ACTH and glucocorticoids, in the body's response to stress. It discusses how these hormones influence various physiological processes, including blood pressure, blood sugar levels, and immune function. The article also addresses the potential for mineral-corticoids to contribute to stress-related diseases, and the interaction between different types of corticoids. The text also discusses the importance of understanding the role of stress in disease, and how the GAS concept can be applied to clinical medicine. It suggests that non-specific therapies, such as fever therapy and shock therapy, may be beneficial due to their effects on the body's stress response. The article also discusses the potential for corticosteroids in the treatment of various diseases, including rheumatoid arthritis and allergies. The article concludes with a discussion of future research directions, including the need to better understand the mechanisms of the GAS concept, the role of adaptation energy, and the relationship between stress-related diseases and periodicity. It also highlights the importance of further research into the potential therapeutic applications of the GAS concept.The article discusses the concept of the general adaptation syndrome (GAS), introduced by Hans Selye, which integrates various physiological and pathological observations into a unified biological system. Selye highlights the importance of maintaining internal stability (homeostasis) and the body's response to stress, which includes three stages: alarm reaction, resistance, and exhaustion. Stressors can cause damage, but the body's defense mechanisms, including the nervous and hormonal systems, help to counteract this damage. The GAS concept suggests that all living organisms respond to stress in a similar manner, and that adaptability is a finite resource influenced by genetic factors. The article also explores the role of various hormones, such as ACTH and glucocorticoids, in the body's response to stress. It discusses how these hormones influence various physiological processes, including blood pressure, blood sugar levels, and immune function. The article also addresses the potential for mineral-corticoids to contribute to stress-related diseases, and the interaction between different types of corticoids. The text also discusses the importance of understanding the role of stress in disease, and how the GAS concept can be applied to clinical medicine. It suggests that non-specific therapies, such as fever therapy and shock therapy, may be beneficial due to their effects on the body's stress response. The article also discusses the potential for corticosteroids in the treatment of various diseases, including rheumatoid arthritis and allergies. The article concludes with a discussion of future research directions, including the need to better understand the mechanisms of the GAS concept, the role of adaptation energy, and the relationship between stress-related diseases and periodicity. It also highlights the importance of further research into the potential therapeutic applications of the GAS concept.