Hans Selye, in his article "Stress and the General Adaptation Syndrome," integrates various observations into a unified biological system. He emphasizes that all living organisms respond to stress through a common pattern, which he calls the "General Adaptation Syndrome" (GAS). This syndrome involves three stages: the "Alarm Reaction," the "Resistance," and the "Exhaustion." Selye highlights that adaptability and resistance to stress are fundamental for life, and that every vital organ and function participates in these processes. Selye discusses the integration of specific defense reactions with the integrated syndrome of adaptive reactions to non-specific stress. He explains the nervous and hormonal defense mechanisms, including the role of adrenergic nerves, the hypothalamic-hypophyseal system, and the production of glucocorticoids and mineralocorticoids. He also addresses the polymorphism of GAS manifestations due to conditioning factors such as heredity, pre-existing diseases, and diet. The article addresses criticisms of the GAS concept, including the polymorphism of diseases of adaptation, the effectiveness of non-specific therapies, and the role of corticoids in treating various conditions. Selye emphasizes the clinical applications of the GAS concept, such as dietary treatments for cardiovascular and renal diseases, and the therapeutic use of corticotropin and corticoids. Finally, Selye outlines future research directions, including the identification of "adaptation energy," the physiopathology of periodicity, the role of the "first mediator" in stress responses, and the potential therapeutic value of components other than adrenaline, corticotropin, and glucocorticoids. He also discusses the correlation between glucocorticoid and anti-arthritic activity, and the correlation between mineralocorticoid and hyalinosis activity.Hans Selye, in his article "Stress and the General Adaptation Syndrome," integrates various observations into a unified biological system. He emphasizes that all living organisms respond to stress through a common pattern, which he calls the "General Adaptation Syndrome" (GAS). This syndrome involves three stages: the "Alarm Reaction," the "Resistance," and the "Exhaustion." Selye highlights that adaptability and resistance to stress are fundamental for life, and that every vital organ and function participates in these processes. Selye discusses the integration of specific defense reactions with the integrated syndrome of adaptive reactions to non-specific stress. He explains the nervous and hormonal defense mechanisms, including the role of adrenergic nerves, the hypothalamic-hypophyseal system, and the production of glucocorticoids and mineralocorticoids. He also addresses the polymorphism of GAS manifestations due to conditioning factors such as heredity, pre-existing diseases, and diet. The article addresses criticisms of the GAS concept, including the polymorphism of diseases of adaptation, the effectiveness of non-specific therapies, and the role of corticoids in treating various conditions. Selye emphasizes the clinical applications of the GAS concept, such as dietary treatments for cardiovascular and renal diseases, and the therapeutic use of corticotropin and corticoids. Finally, Selye outlines future research directions, including the identification of "adaptation energy," the physiopathology of periodicity, the role of the "first mediator" in stress responses, and the potential therapeutic value of components other than adrenaline, corticotropin, and glucocorticoids. He also discusses the correlation between glucocorticoid and anti-arthritic activity, and the correlation between mineralocorticoid and hyalinosis activity.