This paper presents the development of stretchable silicon nanoribbon (SiNR) electronics for skin prosthesis. The authors demonstrate a smart prosthetic skin equipped with ultrathin, single crystalline SiNR strain, pressure, and temperature sensor arrays, as well as humidity sensors, electroresistive heaters, and stretchable multi-electrode arrays for nerve stimulation. These sensors and actuators facilitate highly localized mechanical and thermal skin-like perception in response to external stimuli, enhancing the functionality of emerging prostheses and peripheral nervous system interface technologies. The SiNR sensors are designed to stretch according to the dynamic mechanical properties of the target skin segment, providing high spatio-temporal sensitivity and mechanical reliability. The integration of stretchable humidity sensors and heaters enables the sensation of skin moisture and body temperature regulation, respectively. Electrical stimuli can be transmitted from the prosthetic skin to the body via conformally contacted ultrathin stretchable nanowire-based electrodes, decorated with ceria nanoparticles to control inflammation. The study also includes detailed fabrication procedures, characterization of the sensors and actuators, and in vivo electrophysiological recordings to demonstrate the successful interconnection between the prosthetic skin and peripheral nerves.This paper presents the development of stretchable silicon nanoribbon (SiNR) electronics for skin prosthesis. The authors demonstrate a smart prosthetic skin equipped with ultrathin, single crystalline SiNR strain, pressure, and temperature sensor arrays, as well as humidity sensors, electroresistive heaters, and stretchable multi-electrode arrays for nerve stimulation. These sensors and actuators facilitate highly localized mechanical and thermal skin-like perception in response to external stimuli, enhancing the functionality of emerging prostheses and peripheral nervous system interface technologies. The SiNR sensors are designed to stretch according to the dynamic mechanical properties of the target skin segment, providing high spatio-temporal sensitivity and mechanical reliability. The integration of stretchable humidity sensors and heaters enables the sensation of skin moisture and body temperature regulation, respectively. Electrical stimuli can be transmitted from the prosthetic skin to the body via conformally contacted ultrathin stretchable nanowire-based electrodes, decorated with ceria nanoparticles to control inflammation. The study also includes detailed fabrication procedures, characterization of the sensors and actuators, and in vivo electrophysiological recordings to demonstrate the successful interconnection between the prosthetic skin and peripheral nerves.