The study by Louveau et al. (2015) reveals the existence of a functional lymphatic system in the central nervous system (CNS), which was previously thought to lack such a system. The researchers discovered that the meningeal spaces contain lymphatic vessels lining the dural sinuses, which express key molecular markers of lymphatic endothelial cells and are capable of transporting both fluid and immune cells from the cerebrospinal fluid (CSF). These vessels are connected to deep cervical lymph nodes, suggesting a direct route for the drainage of CSF-derived components into the immune system. The findings challenge the traditional view of the immune privilege of the brain and suggest that dysfunction of these meningeal lymphatics could contribute to neurological disorders associated with immune system dysfunction, such as multiple sclerosis and Alzheimer's disease. The study also highlights the importance of reevaluating current dogmas in neuroimmunology and provides new insights into the pathophysiology of neuroinflammatory and neurodegenerative diseases.The study by Louveau et al. (2015) reveals the existence of a functional lymphatic system in the central nervous system (CNS), which was previously thought to lack such a system. The researchers discovered that the meningeal spaces contain lymphatic vessels lining the dural sinuses, which express key molecular markers of lymphatic endothelial cells and are capable of transporting both fluid and immune cells from the cerebrospinal fluid (CSF). These vessels are connected to deep cervical lymph nodes, suggesting a direct route for the drainage of CSF-derived components into the immune system. The findings challenge the traditional view of the immune privilege of the brain and suggest that dysfunction of these meningeal lymphatics could contribute to neurological disorders associated with immune system dysfunction, such as multiple sclerosis and Alzheimer's disease. The study also highlights the importance of reevaluating current dogmas in neuroimmunology and provides new insights into the pathophysiology of neuroinflammatory and neurodegenerative diseases.