A functional lymphatic system has been identified in the central nervous system (CNS), challenging previous assumptions about the absence of lymphatic drainage in the brain. These lymphatic vessels, located along the dural sinuses, express markers characteristic of lymphatic endothelial cells and are connected to deep cervical lymph nodes. They facilitate the drainage of cerebrospinal fluid (CSF) and immune cells from the CNS, suggesting a new pathway for immune cell egress and CSF drainage. The vessels exhibit features of initial lymphatic vessels, including the absence of smooth muscle cells and expression of CCL21, a chemokine that attracts immune cells. They also display distinct molecular markers such as Prox1, podoplanin, and VEGFR3, and their function is supported by the observation that VEGFR3-specific VEGF-c increases their diameter. These findings indicate that the CNS has a functional lymphatic system, which may have implications for understanding neuroinflammatory and neurodegenerative diseases. The discovery also suggests that the meningeal lymphatic system is a novel pathway for CSF drainage and immune cell trafficking, potentially altering current views on CNS immunity and immune privilege. The study also highlights the importance of these vessels in maintaining immune surveillance and their potential role in neurological disorders. The research involved detailed immunohistochemical and flow cytometric analyses, as well as in vivo imaging and electron microscopy, to characterize the structure and function of these lymphatic vessels. The results suggest that the meningeal lymphatic system is a critical component of CNS immunity and may have significant implications for the treatment of neurological diseases.A functional lymphatic system has been identified in the central nervous system (CNS), challenging previous assumptions about the absence of lymphatic drainage in the brain. These lymphatic vessels, located along the dural sinuses, express markers characteristic of lymphatic endothelial cells and are connected to deep cervical lymph nodes. They facilitate the drainage of cerebrospinal fluid (CSF) and immune cells from the CNS, suggesting a new pathway for immune cell egress and CSF drainage. The vessels exhibit features of initial lymphatic vessels, including the absence of smooth muscle cells and expression of CCL21, a chemokine that attracts immune cells. They also display distinct molecular markers such as Prox1, podoplanin, and VEGFR3, and their function is supported by the observation that VEGFR3-specific VEGF-c increases their diameter. These findings indicate that the CNS has a functional lymphatic system, which may have implications for understanding neuroinflammatory and neurodegenerative diseases. The discovery also suggests that the meningeal lymphatic system is a novel pathway for CSF drainage and immune cell trafficking, potentially altering current views on CNS immunity and immune privilege. The study also highlights the importance of these vessels in maintaining immune surveillance and their potential role in neurological disorders. The research involved detailed immunohistochemical and flow cytometric analyses, as well as in vivo imaging and electron microscopy, to characterize the structure and function of these lymphatic vessels. The results suggest that the meningeal lymphatic system is a critical component of CNS immunity and may have significant implications for the treatment of neurological diseases.