Suicide is a complex global public health issue with significant gender, age, cultural, and geographic variations in prevalence. Despite the lack of a definitive algorithm to predict suicide, improved understanding of clinical, psychological, sociological, and biological factors can enhance the detection of high-risk individuals and guide treatment selection. Psychotherapeutic, pharmacological, and neuromodulatory treatments can prevent suicidal behavior (SB), and regular follow-up of suicide attempters is crucial for preventing future attempts. The paper reviews the epidemiology, risk factors, and effective interventions for SB, emphasizing the importance of early intervention, access to care, and method restriction. It highlights the role of family history, childhood adversity, mental disorders, and social factors in SB, and discusses various interventions, including school-based programs, primary care interventions, and pharmacological treatments. The authors emphasize the need for continued research and public health policies to reduce global suicide rates.Suicide is a complex global public health issue with significant gender, age, cultural, and geographic variations in prevalence. Despite the lack of a definitive algorithm to predict suicide, improved understanding of clinical, psychological, sociological, and biological factors can enhance the detection of high-risk individuals and guide treatment selection. Psychotherapeutic, pharmacological, and neuromodulatory treatments can prevent suicidal behavior (SB), and regular follow-up of suicide attempters is crucial for preventing future attempts. The paper reviews the epidemiology, risk factors, and effective interventions for SB, emphasizing the importance of early intervention, access to care, and method restriction. It highlights the role of family history, childhood adversity, mental disorders, and social factors in SB, and discusses various interventions, including school-based programs, primary care interventions, and pharmacological treatments. The authors emphasize the need for continued research and public health policies to reduce global suicide rates.