Elsevier established a free COVID-19 resource center in January 2020, offering information in English and Mandarin. The center is hosted on Elsevier Connect, and the company grants permission for free access to its research in PubMed Central and other repositories. The resource center aims to support research on the pandemic. The text discusses the challenges of treating bipolar depression, noting that it is a complex condition influenced by various biological and environmental factors. It suggests that single-target therapies may not be effective, and that personalized, multi-faceted approaches are needed. Anti-inflammatory drugs may play a role, but their effectiveness is still under investigation. The article also addresses the mental health impacts of the COVID-19 pandemic, highlighting the increased risk of suicide due to factors like isolation, economic stress, and social isolation. It emphasizes the need for comprehensive suicide prevention strategies, including public health measures, support for vulnerable groups, and responsible media reporting. The text outlines the importance of addressing gender inequalities in adolescent depression, noting that girls are more likely to experience depression due to a combination of biological, psychological, and societal factors. It suggests that gender should be considered as an exposure variable in understanding depression. The article concludes with a call for global collaboration and research to address the mental health challenges posed by the pandemic, emphasizing the need for evidence-based interventions and policies.Elsevier established a free COVID-19 resource center in January 2020, offering information in English and Mandarin. The center is hosted on Elsevier Connect, and the company grants permission for free access to its research in PubMed Central and other repositories. The resource center aims to support research on the pandemic. The text discusses the challenges of treating bipolar depression, noting that it is a complex condition influenced by various biological and environmental factors. It suggests that single-target therapies may not be effective, and that personalized, multi-faceted approaches are needed. Anti-inflammatory drugs may play a role, but their effectiveness is still under investigation. The article also addresses the mental health impacts of the COVID-19 pandemic, highlighting the increased risk of suicide due to factors like isolation, economic stress, and social isolation. It emphasizes the need for comprehensive suicide prevention strategies, including public health measures, support for vulnerable groups, and responsible media reporting. The text outlines the importance of addressing gender inequalities in adolescent depression, noting that girls are more likely to experience depression due to a combination of biological, psychological, and societal factors. It suggests that gender should be considered as an exposure variable in understanding depression. The article concludes with a call for global collaboration and research to address the mental health challenges posed by the pandemic, emphasizing the need for evidence-based interventions and policies.