Since January 2020, Elsevier has established a COVID-19 resource center on its public news and information website, Elsevier Connect, providing free English and Mandarin information on the novel coronavirus. The company has granted permission to make all COVID-19-related research available in PubMed Central and other public repositories, allowing unrestricted reuse and analysis with acknowledgment of the original source. This permission is valid as long as the resource center remains active. The article also discusses the complex nature of bipolar depression, highlighting the heterogeneity of the disorder and the challenges of singular biological therapies. It emphasizes the need for polyvalent and personalized treatments, including pharmacological, neurostimulatory, nutraceutical, lifestyle, and psychological approaches. The potential role of anti-inflammatory drugs in treating bipolar depression is explored, but the promise of this approach is seen as somewhat weaker due to methodological issues. Additionally, the article addresses the mental health impacts of the COVID-19 pandemic, particularly the risk of suicide. It suggests that suicide rates may rise due to fear, self-isolation, and physical distancing, and outlines the need for a wide-ranging interdisciplinary response. This includes selective, indicated, and universal interventions, such as remote mental health services, financial support, and community support for vulnerable groups. The article also highlights the importance of monitoring and surveillance to identify and address increased suicide risk during the pandemic. Finally, the role of gender inequalities in adolescent depression is discussed, noting that women are twice as likely to experience depression compared to men. The gender difference is attributed to both internal factors (such as sex hormones) and external factors (such as societal and environmental influences). Cognitive models of depression suggest that early experiences can lead to negative self-concepts, increasing the risk of depression, and gender is proposed as an exposure variable in this causal process.Since January 2020, Elsevier has established a COVID-19 resource center on its public news and information website, Elsevier Connect, providing free English and Mandarin information on the novel coronavirus. The company has granted permission to make all COVID-19-related research available in PubMed Central and other public repositories, allowing unrestricted reuse and analysis with acknowledgment of the original source. This permission is valid as long as the resource center remains active. The article also discusses the complex nature of bipolar depression, highlighting the heterogeneity of the disorder and the challenges of singular biological therapies. It emphasizes the need for polyvalent and personalized treatments, including pharmacological, neurostimulatory, nutraceutical, lifestyle, and psychological approaches. The potential role of anti-inflammatory drugs in treating bipolar depression is explored, but the promise of this approach is seen as somewhat weaker due to methodological issues. Additionally, the article addresses the mental health impacts of the COVID-19 pandemic, particularly the risk of suicide. It suggests that suicide rates may rise due to fear, self-isolation, and physical distancing, and outlines the need for a wide-ranging interdisciplinary response. This includes selective, indicated, and universal interventions, such as remote mental health services, financial support, and community support for vulnerable groups. The article also highlights the importance of monitoring and surveillance to identify and address increased suicide risk during the pandemic. Finally, the role of gender inequalities in adolescent depression is discussed, noting that women are twice as likely to experience depression compared to men. The gender difference is attributed to both internal factors (such as sex hormones) and external factors (such as societal and environmental influences). Cognitive models of depression suggest that early experiences can lead to negative self-concepts, increasing the risk of depression, and gender is proposed as an exposure variable in this causal process.