A sulfur-TiO₂ yolk-shell nanoarchitecture with internal void space is introduced for long-cycle lithium-sulfur batteries. Sulfur, with a high theoretical capacity of 1,673 mAh g⁻¹, suffers from rapid capacity decay due to polysulfide dissolution and volumetric expansion during lithiation. This study addresses these challenges by designing a yolk-shell structure that accommodates sulfur's volume expansion, preserving the integrity of the TiO₂ shell and minimizing polysulfide dissolution. The yolk-shell nanostructures achieved an initial specific capacity of 1,030 mAh g⁻¹ at 0.5 C and a Coulombic efficiency of 98.4% over 1,000 cycles, with a capacity decay of only 0.033% per cycle, representing the best performance for long-cycle lithium-sulfur batteries. The design effectively mitigates polysulfide dissolution through the presence of internal void space, allowing the TiO₂ shell to remain intact. The yolk-shell nanostructures outperformed bare sulfur and sulfur-TiO₂ core-shell nanoparticles in terms of capacity retention. The study highlights the potential of this nanoarchitecture for future high-performance rechargeable batteries.A sulfur-TiO₂ yolk-shell nanoarchitecture with internal void space is introduced for long-cycle lithium-sulfur batteries. Sulfur, with a high theoretical capacity of 1,673 mAh g⁻¹, suffers from rapid capacity decay due to polysulfide dissolution and volumetric expansion during lithiation. This study addresses these challenges by designing a yolk-shell structure that accommodates sulfur's volume expansion, preserving the integrity of the TiO₂ shell and minimizing polysulfide dissolution. The yolk-shell nanostructures achieved an initial specific capacity of 1,030 mAh g⁻¹ at 0.5 C and a Coulombic efficiency of 98.4% over 1,000 cycles, with a capacity decay of only 0.033% per cycle, representing the best performance for long-cycle lithium-sulfur batteries. The design effectively mitigates polysulfide dissolution through the presence of internal void space, allowing the TiO₂ shell to remain intact. The yolk-shell nanostructures outperformed bare sulfur and sulfur-TiO₂ core-shell nanoparticles in terms of capacity retention. The study highlights the potential of this nanoarchitecture for future high-performance rechargeable batteries.