This review provides an overview of the superhydrophobic surface (SHS)-assisted strategies for fabricating microspheres and supraparticles, along with their applications and challenges. SHS, characterized by a contact angle greater than 150° and low adhesion, facilitates the formation of spherical droplets and easy droplet collection. The fabrication strategies include cross-linking curing, polymer melting, and droplet template evaporation methods. Microspheres and supraparticles have diverse applications, such as photonic devices, catalysts, biomedical devices, and trace analyte detection. The review discusses the advantages of SHS-assisted fabrication, including material savings, reduced pollution, and high throughput production. It also highlights the potential of superamphiphobic surfaces (SAS) for fabricating microspheres and supraparticles from various liquid droplets. The review further explores the fabrication of microspheres and supraparticles using different methods, the formation of microsphere-like materials, and the creation of supraparticles with controllable sizes, diverse morphologies, and tailored properties. Finally, it discusses the applications of these materials in colloidal photonic crystals, catalysts, and biomedical fields, emphasizing their potential in drug delivery and cell encapsulation.This review provides an overview of the superhydrophobic surface (SHS)-assisted strategies for fabricating microspheres and supraparticles, along with their applications and challenges. SHS, characterized by a contact angle greater than 150° and low adhesion, facilitates the formation of spherical droplets and easy droplet collection. The fabrication strategies include cross-linking curing, polymer melting, and droplet template evaporation methods. Microspheres and supraparticles have diverse applications, such as photonic devices, catalysts, biomedical devices, and trace analyte detection. The review discusses the advantages of SHS-assisted fabrication, including material savings, reduced pollution, and high throughput production. It also highlights the potential of superamphiphobic surfaces (SAS) for fabricating microspheres and supraparticles from various liquid droplets. The review further explores the fabrication of microspheres and supraparticles using different methods, the formation of microsphere-like materials, and the creation of supraparticles with controllable sizes, diverse morphologies, and tailored properties. Finally, it discusses the applications of these materials in colloidal photonic crystals, catalysts, and biomedical fields, emphasizing their potential in drug delivery and cell encapsulation.