A systematic review and meta-analysis of surgical interventions for intractable migraine found that procedures such as occipital nerve stimulation (ONS) and nerve decompression significantly reduced migraine intensity. Eleven studies were included, with four showing a significant reduction in mean migraine intensity scores using ONS (-2.27, 95% CI: -3.92 to -0.63, P=0.021). Three studies showed a reduction in Migraine Disability Assessment (MIDAS) scores, though not statistically significant. Nerve decompression surgery showed substantial decreases in migraine intensity and varying success rates in reducing migraine Headache Index (MHI). Septorhinoplasty and sinus surgery were also effective in reducing migraine intensity. The study highlights the potential of surgical interventions for intractable migraines but emphasizes the need for further research to confirm their efficacy and address cost-effectiveness. The findings suggest that surgical approaches could be a promising alternative for patients who do not respond to conventional treatments. However, the study acknowledges limitations, including the reliance on patient-reported outcomes and the lack of a control group. The results indicate that surgical interventions may offer therapeutic benefits for intractable migraines, but more comprehensive research is needed to validate these findings and ensure their widespread application.A systematic review and meta-analysis of surgical interventions for intractable migraine found that procedures such as occipital nerve stimulation (ONS) and nerve decompression significantly reduced migraine intensity. Eleven studies were included, with four showing a significant reduction in mean migraine intensity scores using ONS (-2.27, 95% CI: -3.92 to -0.63, P=0.021). Three studies showed a reduction in Migraine Disability Assessment (MIDAS) scores, though not statistically significant. Nerve decompression surgery showed substantial decreases in migraine intensity and varying success rates in reducing migraine Headache Index (MHI). Septorhinoplasty and sinus surgery were also effective in reducing migraine intensity. The study highlights the potential of surgical interventions for intractable migraines but emphasizes the need for further research to confirm their efficacy and address cost-effectiveness. The findings suggest that surgical approaches could be a promising alternative for patients who do not respond to conventional treatments. However, the study acknowledges limitations, including the reliance on patient-reported outcomes and the lack of a control group. The results indicate that surgical interventions may offer therapeutic benefits for intractable migraines, but more comprehensive research is needed to validate these findings and ensure their widespread application.