The report summarizes the progress toward polio eradication worldwide from 2022 to 2023. Since 1988, wild poliovirus (WPV) cases have decreased by over 99.9%, and WPV serotypes 2 and 3 have been eradicated. Only WPV1 remains, circulating in Afghanistan and Pakistan. During 2022–2023, 20 out of 28 priority countries met national AFP surveillance targets, with an increase in environmental surveillance sites. However, some countries still have gaps in AFP surveillance, possibly due to reporting delays. The Global Polio Laboratory Network (GPLN) tested 233,437 stool specimens, with most results reported within 14 days of specimen receipt. In 2023, no WPV1 cases were detected outside Afghanistan and Pakistan. The number of cVDPV cases decreased, but cVDPV2 cases remained a concern. Environmental surveillance showed increased sensitivity in some regions, but declines were noted in Somalia and Sudan. The GPLN detected WPV1 in Afghanistan and Pakistan, with most isolates linked to the YB3A genetic cluster. The report emphasizes the importance of maintaining high-quality surveillance to achieve global polio eradication, particularly in high-risk countries. Limitations include data delays and potential underreporting in hard-to-reach areas. The findings highlight the need for continued surveillance and response efforts to prevent poliovirus transmission.The report summarizes the progress toward polio eradication worldwide from 2022 to 2023. Since 1988, wild poliovirus (WPV) cases have decreased by over 99.9%, and WPV serotypes 2 and 3 have been eradicated. Only WPV1 remains, circulating in Afghanistan and Pakistan. During 2022–2023, 20 out of 28 priority countries met national AFP surveillance targets, with an increase in environmental surveillance sites. However, some countries still have gaps in AFP surveillance, possibly due to reporting delays. The Global Polio Laboratory Network (GPLN) tested 233,437 stool specimens, with most results reported within 14 days of specimen receipt. In 2023, no WPV1 cases were detected outside Afghanistan and Pakistan. The number of cVDPV cases decreased, but cVDPV2 cases remained a concern. Environmental surveillance showed increased sensitivity in some regions, but declines were noted in Somalia and Sudan. The GPLN detected WPV1 in Afghanistan and Pakistan, with most isolates linked to the YB3A genetic cluster. The report emphasizes the importance of maintaining high-quality surveillance to achieve global polio eradication, particularly in high-risk countries. Limitations include data delays and potential underreporting in hard-to-reach areas. The findings highlight the need for continued surveillance and response efforts to prevent poliovirus transmission.