This review article, authored by Ángeles Morón-Ortiz, Paula Mapelli-Brahm, and Antonio J. Meléndez-Martínez, focuses on the sustainable extraction of carotenoids using innovative technologies and bio-based solvents. Carotenoids, versatile isoprenoid compounds found in various food sources, are known for their health benefits, including provitamin A activity and potential anti-inflammatory effects. The authors highlight the importance of carotenoids in food production and health promotion, emphasizing the need for greener processes and solvents in the biorefinery process to align with the circular economy paradigm. The review covers a range of extraction technologies, including ultrasound-assisted extraction (UAE), microwave-assisted extraction (MAE), pulsed electric field (PEF), pressurized liquid extraction (PLE), sub- and supercritical fluid extraction, and enzyme-assisted extraction. Each technology is evaluated based on its efficiency, energy consumption, and environmental impact. Additionally, the article discusses the use of green solvents such as ethyl lactate, 2-methyltetrahydrofuran (2-MeTHF), natural deep eutectic solvents (NaDESs), deep eutectic solvents (DESs), and ionic liquids (ILs) as alternatives to more toxic and less environmentally friendly solvents. The authors conclude that while laboratory results are promising, scaling up these technologies to industrial levels poses significant challenges. They emphasize the importance of incorporating life cycle assessment analyses to comprehensively evaluate the sustainability of innovative extraction processes compared to industry-standard methods. The review provides a comprehensive overview of the current state of research in sustainable carotenoid extraction, highlighting the potential of green technologies and solvents to meet the growing demand for carotenoids in functional foods and nutraceuticals.This review article, authored by Ángeles Morón-Ortiz, Paula Mapelli-Brahm, and Antonio J. Meléndez-Martínez, focuses on the sustainable extraction of carotenoids using innovative technologies and bio-based solvents. Carotenoids, versatile isoprenoid compounds found in various food sources, are known for their health benefits, including provitamin A activity and potential anti-inflammatory effects. The authors highlight the importance of carotenoids in food production and health promotion, emphasizing the need for greener processes and solvents in the biorefinery process to align with the circular economy paradigm. The review covers a range of extraction technologies, including ultrasound-assisted extraction (UAE), microwave-assisted extraction (MAE), pulsed electric field (PEF), pressurized liquid extraction (PLE), sub- and supercritical fluid extraction, and enzyme-assisted extraction. Each technology is evaluated based on its efficiency, energy consumption, and environmental impact. Additionally, the article discusses the use of green solvents such as ethyl lactate, 2-methyltetrahydrofuran (2-MeTHF), natural deep eutectic solvents (NaDESs), deep eutectic solvents (DESs), and ionic liquids (ILs) as alternatives to more toxic and less environmentally friendly solvents. The authors conclude that while laboratory results are promising, scaling up these technologies to industrial levels poses significant challenges. They emphasize the importance of incorporating life cycle assessment analyses to comprehensively evaluate the sustainability of innovative extraction processes compared to industry-standard methods. The review provides a comprehensive overview of the current state of research in sustainable carotenoid extraction, highlighting the potential of green technologies and solvents to meet the growing demand for carotenoids in functional foods and nutraceuticals.