This study presents a novel 3D piezoelectric fabric (3DPF) sensor made from PVDF piezoelectric nanoyarns, which are woven with different yarns to form a breathable and durable fabric. The PVDF nanoyarns, with an ultra-high strength of 313.3 MPa, are combined with conductive and non-conductive yarns to create a 3DPF sensor. This sensor exhibits excellent anti-gravity unidirectional liquid transport, allowing sweat to move from the inner layer to the outer layer in 4 seconds, ensuring a comfortable and dry environment for the user. The 3DPF's piezoelectric properties are enhanced by human sweating, with sensitivity increasing from 0.41 V KPa\(^{-1}\) in dry conditions to 3.95 V KPa\(^{-1}\) when wet. The sensor also demonstrates high durability and comfort, with a tensile strength of 46.0 MPa and wear resistance comparable to commercial cotton T-shirts. The 3DPF can be used as a self-powered switch for applications such as bed sheets and children's belts, providing intelligent healthcare and safety features. The study highlights the potential of this 3DPF sensor for long-term wearable applications due to its balance between comfort and sensing properties.This study presents a novel 3D piezoelectric fabric (3DPF) sensor made from PVDF piezoelectric nanoyarns, which are woven with different yarns to form a breathable and durable fabric. The PVDF nanoyarns, with an ultra-high strength of 313.3 MPa, are combined with conductive and non-conductive yarns to create a 3DPF sensor. This sensor exhibits excellent anti-gravity unidirectional liquid transport, allowing sweat to move from the inner layer to the outer layer in 4 seconds, ensuring a comfortable and dry environment for the user. The 3DPF's piezoelectric properties are enhanced by human sweating, with sensitivity increasing from 0.41 V KPa\(^{-1}\) in dry conditions to 3.95 V KPa\(^{-1}\) when wet. The sensor also demonstrates high durability and comfort, with a tensile strength of 46.0 MPa and wear resistance comparable to commercial cotton T-shirts. The 3DPF can be used as a self-powered switch for applications such as bed sheets and children's belts, providing intelligent healthcare and safety features. The study highlights the potential of this 3DPF sensor for long-term wearable applications due to its balance between comfort and sensing properties.