This review article by Babay Asih Suliasih, Setia Budi, and Haliza Katas explores the synthesis and application of gold nanoparticles (AuNPs) as antioxidants. The authors highlight the growing demand for effective antioxidants due to the increasing prevalence of non-communicable diseases (NCDs) and premature aging caused by free radicals. AuNPs are favored for their minimal toxicity, simple synthesis, and detectability, making them suitable for various healthcare applications such as anti-aging, anti-inflammatory, and wound healing agents. The review discusses the synthesis methods of AuNPs, including top-down and bottom-up approaches, and the assessment of their antioxidant capacity using in vitro and in vivo methods. The mechanisms of action of AuNPs as antioxidants are also examined, including their catalase-mimic and superoxide dismutase-mimic behaviors. The physicochemical properties of AuNPs, such as size, shape, and surface chemistry, are found to significantly influence their antioxidant activity. The potential health applications of AuNPs are explored, including their use in skin aging management, wound healing, and the treatment of various diseases such as atherosclerosis, inflammatory conditions, neurodegenerative diseases, and bone loss. The authors conclude that AuNPs are promising and effective antioxidants with significant potential for clinical applications, considering their physicochemical and biological properties, benefits, and potential challenges for future development.This review article by Babay Asih Suliasih, Setia Budi, and Haliza Katas explores the synthesis and application of gold nanoparticles (AuNPs) as antioxidants. The authors highlight the growing demand for effective antioxidants due to the increasing prevalence of non-communicable diseases (NCDs) and premature aging caused by free radicals. AuNPs are favored for their minimal toxicity, simple synthesis, and detectability, making them suitable for various healthcare applications such as anti-aging, anti-inflammatory, and wound healing agents. The review discusses the synthesis methods of AuNPs, including top-down and bottom-up approaches, and the assessment of their antioxidant capacity using in vitro and in vivo methods. The mechanisms of action of AuNPs as antioxidants are also examined, including their catalase-mimic and superoxide dismutase-mimic behaviors. The physicochemical properties of AuNPs, such as size, shape, and surface chemistry, are found to significantly influence their antioxidant activity. The potential health applications of AuNPs are explored, including their use in skin aging management, wound healing, and the treatment of various diseases such as atherosclerosis, inflammatory conditions, neurodegenerative diseases, and bone loss. The authors conclude that AuNPs are promising and effective antioxidants with significant potential for clinical applications, considering their physicochemical and biological properties, benefits, and potential challenges for future development.