Elsevier has created a free COVID-19 resource centre with English and Mandarin information since January 2020, hosted on Elsevier Connect. The company grants permission to make all its COVID-19-related research freely available in PubMed Central and other repositories for research reuse. A systematic review of health-related misinformation on social media is conducted, analyzing 57 articles published between 2012 and 2018. The review finds an increasing trend in research on misinformation, with topics including vaccination, Ebola, Zika, and others. Studies use content analysis, social network analysis, and experiments, drawing from psychology, network science, and other disciplines. Misinformation spreads rapidly on social media, often fueled by sensationalized content and confirmation bias. The review highlights the role of belief systems and socio-demographic factors in susceptibility to misinformation. It calls for interdisciplinary research to develop effective interventions. The review also notes gaps in understanding the mechanisms of misinformation spread and the need for more research on susceptible populations. The study emphasizes the importance of critical thinking and media literacy in combating misinformation. The review concludes that misinformation poses significant risks to public health and requires collaborative efforts across disciplines to address the issue.Elsevier has created a free COVID-19 resource centre with English and Mandarin information since January 2020, hosted on Elsevier Connect. The company grants permission to make all its COVID-19-related research freely available in PubMed Central and other repositories for research reuse. A systematic review of health-related misinformation on social media is conducted, analyzing 57 articles published between 2012 and 2018. The review finds an increasing trend in research on misinformation, with topics including vaccination, Ebola, Zika, and others. Studies use content analysis, social network analysis, and experiments, drawing from psychology, network science, and other disciplines. Misinformation spreads rapidly on social media, often fueled by sensationalized content and confirmation bias. The review highlights the role of belief systems and socio-demographic factors in susceptibility to misinformation. It calls for interdisciplinary research to develop effective interventions. The review also notes gaps in understanding the mechanisms of misinformation spread and the need for more research on susceptible populations. The study emphasizes the importance of critical thinking and media literacy in combating misinformation. The review concludes that misinformation poses significant risks to public health and requires collaborative efforts across disciplines to address the issue.