This review provides a systemic analysis of glyphosate's impact on the environment and human health. Glyphosate, a widely used herbicide, has been effective in agriculture but has raised concerns due to its environmental persistence and potential health risks. Its use has led to the development of glyphosate-resistant weeds, which threaten agricultural productivity. Glyphosate residues persist in soil and water, posing risks to non-target organisms. The herbicide's toxicity to various organisms, including humans, animals, and microorganisms, has been documented, with potential impacts on reproductive systems, neurological functions, and organ damage. Glyphosate's chemical structure and mechanism of action, which inhibit the shikimate pathway in plants, contribute to its effectiveness but also its environmental and health concerns. The global market for glyphosate is projected to grow significantly, driven by agricultural demand and the use of genetically modified herbicide-tolerant crops. However, the increasing resistance of weeds and the environmental persistence of glyphosate residues highlight the need for sustainable management practices. The review also discusses various methods of glyphosate degradation, including chemical, microbial, and photodegradation processes, and highlights the challenges in managing glyphosate's environmental impact. Overall, the review emphasizes the importance of balancing the benefits of glyphosate in agriculture with its potential risks to human health and the environment.This review provides a systemic analysis of glyphosate's impact on the environment and human health. Glyphosate, a widely used herbicide, has been effective in agriculture but has raised concerns due to its environmental persistence and potential health risks. Its use has led to the development of glyphosate-resistant weeds, which threaten agricultural productivity. Glyphosate residues persist in soil and water, posing risks to non-target organisms. The herbicide's toxicity to various organisms, including humans, animals, and microorganisms, has been documented, with potential impacts on reproductive systems, neurological functions, and organ damage. Glyphosate's chemical structure and mechanism of action, which inhibit the shikimate pathway in plants, contribute to its effectiveness but also its environmental and health concerns. The global market for glyphosate is projected to grow significantly, driven by agricultural demand and the use of genetically modified herbicide-tolerant crops. However, the increasing resistance of weeds and the environmental persistence of glyphosate residues highlight the need for sustainable management practices. The review also discusses various methods of glyphosate degradation, including chemical, microbial, and photodegradation processes, and highlights the challenges in managing glyphosate's environmental impact. Overall, the review emphasizes the importance of balancing the benefits of glyphosate in agriculture with its potential risks to human health and the environment.