The article provides a comprehensive systemic analysis of the impact of glyphosate on the environment and human health. Glyphosate, a widely used herbicide, has become a significant concern due to its persistence in the environment and potential health risks. The review highlights the chemical properties, global consumption, and market forecast of glyphosate, emphasizing its broad-spectrum effectiveness and increasing demand. However, the misuse of glyphosate has led to environmental degradation, including water and soil contamination, and the development of weed resistance. The article also discusses the mode of action of glyphosate, which involves inhibiting the shikimate pathway in plants, leading to their death. Additionally, it explores the degradation mechanisms of glyphosate, including chemical decomposition, microbial degradation, and photodegradation. The impact of glyphosate on human health is a critical concern, with studies indicating potential acute and chronic toxicity, carcinogenicity, and genotoxicity. The article further examines the effects of glyphosate on various living organisms, including animals, invertebrates, and vertebrates, highlighting both direct and indirect impacts. Finally, the environmental impact of glyphosate is discussed, focusing on its persistence in ecosystems, resistance in weeds, and the need for better monitoring and management practices to mitigate its adverse effects.The article provides a comprehensive systemic analysis of the impact of glyphosate on the environment and human health. Glyphosate, a widely used herbicide, has become a significant concern due to its persistence in the environment and potential health risks. The review highlights the chemical properties, global consumption, and market forecast of glyphosate, emphasizing its broad-spectrum effectiveness and increasing demand. However, the misuse of glyphosate has led to environmental degradation, including water and soil contamination, and the development of weed resistance. The article also discusses the mode of action of glyphosate, which involves inhibiting the shikimate pathway in plants, leading to their death. Additionally, it explores the degradation mechanisms of glyphosate, including chemical decomposition, microbial degradation, and photodegradation. The impact of glyphosate on human health is a critical concern, with studies indicating potential acute and chronic toxicity, carcinogenicity, and genotoxicity. The article further examines the effects of glyphosate on various living organisms, including animals, invertebrates, and vertebrates, highlighting both direct and indirect impacts. Finally, the environmental impact of glyphosate is discussed, focusing on its persistence in ecosystems, resistance in weeds, and the need for better monitoring and management practices to mitigate its adverse effects.