The review discusses the systemic effects of chronic obstructive pulmonary disease (COPD), which are clinically significant and can influence the assessment and management of the disease. These effects include systemic inflammation, nutritional abnormalities and weight loss, skeletal muscle dysfunction, and other potential systemic impacts. Systemic inflammation is characterized by increased levels of proinflammatory cytokines, oxidative stress, and activated inflammatory cells. Nutritional abnormalities and weight loss are common in COPD patients, with weight loss being a poor prognostic factor. Skeletal muscle dysfunction (SMD) is a significant contributor to exercise limitation and can be influenced by sedentarism, tissue hypoxia, systemic inflammation, and oxidative stress. Other potential systemic effects include cardiovascular, nervous system, and osteoskeletal impacts. The review highlights the need for further research to understand and manage these systemic effects, which can improve the health status and prognosis of COPD patients.The review discusses the systemic effects of chronic obstructive pulmonary disease (COPD), which are clinically significant and can influence the assessment and management of the disease. These effects include systemic inflammation, nutritional abnormalities and weight loss, skeletal muscle dysfunction, and other potential systemic impacts. Systemic inflammation is characterized by increased levels of proinflammatory cytokines, oxidative stress, and activated inflammatory cells. Nutritional abnormalities and weight loss are common in COPD patients, with weight loss being a poor prognostic factor. Skeletal muscle dysfunction (SMD) is a significant contributor to exercise limitation and can be influenced by sedentarism, tissue hypoxia, systemic inflammation, and oxidative stress. Other potential systemic effects include cardiovascular, nervous system, and osteoskeletal impacts. The review highlights the need for further research to understand and manage these systemic effects, which can improve the health status and prognosis of COPD patients.