The thesis titled "Efficacy and Responses Activated by Defense-Inducing Molecules in Banana (Musa AAA) Against the Fungus Pseudocercospora fijiensis in the Urabá Subregion" by Diana Cristina Henao Ochoa, a student at the Universidad Nacional de Colombia, addresses the issue of Black Sigatoka, a devastating foliar disease in banana cultivation. The current management strategies, which include cultural and chemical approaches such as phytosanitary defoliation and fungicide applications, have led to the selection of resistant fungal populations over time. To address this, the study proposes an alternative strategy based on the foliar application of defense inducers to activate plants' resistance mechanisms. The research involved direct inhibition tests of various defense-inducing compounds against two strains of *P. fijiensis* (C139 and Pf022101), which did not show significant direct inhibition. However, the controlling capacity of five defense-inducing molecules was evaluated in experimental banana plots in Apartadó, Colombia, with natural pathogen infection. This led to the selection of three potential compounds for managing the disease. Additionally, the effectiveness of these three defense-inducing molecules in a commercial disease management plan was determined, showing that they could replace at least three cycles of chemically synthesized fungicide applications while maintaining or improving disease control. The study highlights the potential of using defense inducers as a preventive and curative alternative to chemical fungicides, reducing environmental impact, health risks, and the selection of resistant fungal populations. The research also contributes to the development of clean agricultural technologies for managing other economic crops in Antioquia, Colombia.The thesis titled "Efficacy and Responses Activated by Defense-Inducing Molecules in Banana (Musa AAA) Against the Fungus Pseudocercospora fijiensis in the Urabá Subregion" by Diana Cristina Henao Ochoa, a student at the Universidad Nacional de Colombia, addresses the issue of Black Sigatoka, a devastating foliar disease in banana cultivation. The current management strategies, which include cultural and chemical approaches such as phytosanitary defoliation and fungicide applications, have led to the selection of resistant fungal populations over time. To address this, the study proposes an alternative strategy based on the foliar application of defense inducers to activate plants' resistance mechanisms. The research involved direct inhibition tests of various defense-inducing compounds against two strains of *P. fijiensis* (C139 and Pf022101), which did not show significant direct inhibition. However, the controlling capacity of five defense-inducing molecules was evaluated in experimental banana plots in Apartadó, Colombia, with natural pathogen infection. This led to the selection of three potential compounds for managing the disease. Additionally, the effectiveness of these three defense-inducing molecules in a commercial disease management plan was determined, showing that they could replace at least three cycles of chemically synthesized fungicide applications while maintaining or improving disease control. The study highlights the potential of using defense inducers as a preventive and curative alternative to chemical fungicides, reducing environmental impact, health risks, and the selection of resistant fungal populations. The research also contributes to the development of clean agricultural technologies for managing other economic crops in Antioquia, Colombia.