The study investigates the role of TEAD transcription factors in mediating YAP-dependent gene expression and cell growth control. TEAD is identified as a key component in the Hippo pathway, which regulates cell and tissue growth. The authors demonstrate that TEAD is essential for YAP-induced gene expression, cell growth, and epithelial-mesenchymal transition (EMT). CTGF is identified as a direct target gene of YAP and TEAD, and its knockdown blocks YAP-stimulated cell growth. The functional relationship between YAP and TEAD is conserved in Drosophila, where Yki (the YAP homolog) and Scalloped (the TEAD homolog) genetically interact to enhance tissue growth and organ size. These findings establish TEAD as a critical transcription factor in mediating YAP function in both mammalian and Drosophila cells.The study investigates the role of TEAD transcription factors in mediating YAP-dependent gene expression and cell growth control. TEAD is identified as a key component in the Hippo pathway, which regulates cell and tissue growth. The authors demonstrate that TEAD is essential for YAP-induced gene expression, cell growth, and epithelial-mesenchymal transition (EMT). CTGF is identified as a direct target gene of YAP and TEAD, and its knockdown blocks YAP-stimulated cell growth. The functional relationship between YAP and TEAD is conserved in Drosophila, where Yki (the YAP homolog) and Scalloped (the TEAD homolog) genetically interact to enhance tissue growth and organ size. These findings establish TEAD as a critical transcription factor in mediating YAP function in both mammalian and Drosophila cells.