The article discusses the importance of the United States Pharmacopeia (USP) and the need for more active involvement from physicians in its revision. Dr. Robert A. Hatcher highlights two main issues: the lack of interest from physicians in the revision process and the need for a more progressive approach to admissions and dismissals. He argues that the USP should only include the best and most scientifically validated remedies, regardless of their nature, while removing any articles of doubtful value. Dr. Hatcher emphasizes the importance of clinical and pharmacological testing, advocating for the exclusion of compounds like compound acetanilid powder and outdated substances like sarsaparilla. He calls for a committee with expertise in pharmacology and clinical research to ensure the USP remains a reliable guide for physicians. The discussion following the article includes various perspectives on the role of physicians in the USP's development, with some emphasizing the need for a larger, more comprehensive reference book, while others highlight the importance of maintaining the USP as a legal standard for drug purity and strength.The article discusses the importance of the United States Pharmacopeia (USP) and the need for more active involvement from physicians in its revision. Dr. Robert A. Hatcher highlights two main issues: the lack of interest from physicians in the revision process and the need for a more progressive approach to admissions and dismissals. He argues that the USP should only include the best and most scientifically validated remedies, regardless of their nature, while removing any articles of doubtful value. Dr. Hatcher emphasizes the importance of clinical and pharmacological testing, advocating for the exclusion of compounds like compound acetanilid powder and outdated substances like sarsaparilla. He calls for a committee with expertise in pharmacology and clinical research to ensure the USP remains a reliable guide for physicians. The discussion following the article includes various perspectives on the role of physicians in the USP's development, with some emphasizing the need for a larger, more comprehensive reference book, while others highlight the importance of maintaining the USP as a legal standard for drug purity and strength.