The TRANSFAC® and TRANSCompel® databases have been updated to enhance their functionality and data coverage. The new web interface offers improved search options and integrates Match™ and Patch™ for transcription factor binding site searches. The databases now link to Ensembl, UniGene, EntrezGene, HumanPSD™, and TRANSPRO™. Standard gene names from HGNC, MGI, and RGD are included for human, mouse, and rat genes. InterProScan, Pfam, SMART, and PROSITE are used to automatically assign domains to transcription factor sequences. TRANSCompel® now includes a separate table for detailed experimental evidence on composite elements. The databases have expanded with data on Drosophila and Arabidopsis transcription factors. The TRANSFAC® 7.0 and TRANSCompel® 7.0 databases are available online. The databases contain primary data on transcription factors, their binding sites, and regulated genes, as well as secondary data like nucleotide distribution matrices and factor classification. The databases are linked to other databases such as HumanPSD™, TRANSPRO™, Ensembl, and UniGene. The new web interface allows simultaneous searches across all tables and provides options for batch searches and result customization. The databases are freely available for non-profit organizations. The work was supported by various grants from the German Ministry of Education and Research and the European Commission. No conflicts of interest were declared.The TRANSFAC® and TRANSCompel® databases have been updated to enhance their functionality and data coverage. The new web interface offers improved search options and integrates Match™ and Patch™ for transcription factor binding site searches. The databases now link to Ensembl, UniGene, EntrezGene, HumanPSD™, and TRANSPRO™. Standard gene names from HGNC, MGI, and RGD are included for human, mouse, and rat genes. InterProScan, Pfam, SMART, and PROSITE are used to automatically assign domains to transcription factor sequences. TRANSCompel® now includes a separate table for detailed experimental evidence on composite elements. The databases have expanded with data on Drosophila and Arabidopsis transcription factors. The TRANSFAC® 7.0 and TRANSCompel® 7.0 databases are available online. The databases contain primary data on transcription factors, their binding sites, and regulated genes, as well as secondary data like nucleotide distribution matrices and factor classification. The databases are linked to other databases such as HumanPSD™, TRANSPRO™, Ensembl, and UniGene. The new web interface allows simultaneous searches across all tables and provides options for batch searches and result customization. The databases are freely available for non-profit organizations. The work was supported by various grants from the German Ministry of Education and Research and the European Commission. No conflicts of interest were declared.