This study presents a sustainable approach to valorize chlorine-containing hydrocarbon waste, including solids (chlorinated polymers) and liquids (chlorinated solvents), by using copper and palladium catalysts with a NaNO3 promoter. The process oxidizes the waste to release chlorine, which is then transferred to an arene to form valuable aryl chlorides, such as the FDA-approved drug vismodegib. The remaining hydrocarbon component is mineralized into CO, CO2, and H2O. The CO and CO2 generated can be further utilized directly. This tandem catalytic approach offers a promising method for the management of a wide range of chlorine-containing hydrocarbon wastes, avoiding the generation of hazardous by-products and the need for specialized chlorination reagents. The method is demonstrated through the synthesis of vismodegib, showing a lower environmental impact compared to conventional chlorination processes.This study presents a sustainable approach to valorize chlorine-containing hydrocarbon waste, including solids (chlorinated polymers) and liquids (chlorinated solvents), by using copper and palladium catalysts with a NaNO3 promoter. The process oxidizes the waste to release chlorine, which is then transferred to an arene to form valuable aryl chlorides, such as the FDA-approved drug vismodegib. The remaining hydrocarbon component is mineralized into CO, CO2, and H2O. The CO and CO2 generated can be further utilized directly. This tandem catalytic approach offers a promising method for the management of a wide range of chlorine-containing hydrocarbon wastes, avoiding the generation of hazardous by-products and the need for specialized chlorination reagents. The method is demonstrated through the synthesis of vismodegib, showing a lower environmental impact compared to conventional chlorination processes.