This review discusses targeted therapeutic strategies for cancer treatment, focusing on overcoming resistance to conventional therapies like chemotherapy, radiotherapy, and immunotherapy. The article highlights the importance of drug combinations and dual inhibitors in improving treatment outcomes. It presents various drug delivery systems, including liposomes, polymeric nanoparticles, micelles, dendrimers, and carbon nanotubes, which offer targeted drug release and enhanced therapeutic efficacy. The review also explores different drug release mechanisms, such as diffusion-based, swelling-based, external stimuli-based, and chemical cleavage-based release, which are crucial for effective cancer treatment. Additionally, the article discusses multi-target therapies, emphasizing the use of combination therapies and dual inhibitors to target multiple pathways and overcome resistance. The review concludes that targeted therapies, drug combinations, and dual inhibitors represent promising strategies for improving cancer treatment and patient outcomes.This review discusses targeted therapeutic strategies for cancer treatment, focusing on overcoming resistance to conventional therapies like chemotherapy, radiotherapy, and immunotherapy. The article highlights the importance of drug combinations and dual inhibitors in improving treatment outcomes. It presents various drug delivery systems, including liposomes, polymeric nanoparticles, micelles, dendrimers, and carbon nanotubes, which offer targeted drug release and enhanced therapeutic efficacy. The review also explores different drug release mechanisms, such as diffusion-based, swelling-based, external stimuli-based, and chemical cleavage-based release, which are crucial for effective cancer treatment. Additionally, the article discusses multi-target therapies, emphasizing the use of combination therapies and dual inhibitors to target multiple pathways and overcome resistance. The review concludes that targeted therapies, drug combinations, and dual inhibitors represent promising strategies for improving cancer treatment and patient outcomes.