The article discusses the role of cellular senescence in age-related endocrine dysfunction and introduces novel interventions targeting senescent cells. Cellular senescence, a process where cells lose the ability to divide and become metabolically active, is implicated in various age-related disorders such as osteoporosis, metabolic syndrome, and type 2 diabetes. Senolytics, drugs that selectively eliminate senescent cells, and senomorphics, drugs that reduce the harmful effects of senescent cells, show promise in delaying or alleviating these diseases. Over 30 clinical trials of senolytic and senomorphic agents are underway or planned. The accumulation of senescent cells in endocrine organs with aging contributes to dysfunction and disease, and targeting these cells offers a novel strategy to address age-related health issues. The article also highlights the potential benefits of senolytic and senomorphic interventions in combination with hormone replacement therapy (HRT) and other established treatments, potentially reducing side effects and improving outcomes.The article discusses the role of cellular senescence in age-related endocrine dysfunction and introduces novel interventions targeting senescent cells. Cellular senescence, a process where cells lose the ability to divide and become metabolically active, is implicated in various age-related disorders such as osteoporosis, metabolic syndrome, and type 2 diabetes. Senolytics, drugs that selectively eliminate senescent cells, and senomorphics, drugs that reduce the harmful effects of senescent cells, show promise in delaying or alleviating these diseases. Over 30 clinical trials of senolytic and senomorphic agents are underway or planned. The accumulation of senescent cells in endocrine organs with aging contributes to dysfunction and disease, and targeting these cells offers a novel strategy to address age-related health issues. The article also highlights the potential benefits of senolytic and senomorphic interventions in combination with hormone replacement therapy (HRT) and other established treatments, potentially reducing side effects and improving outcomes.