The article "Targeting Dysregulated Lipid Metabolism in Cancer with Pharmacological Inhibitors" by Amogh Gupta, Dipanwita Das, and Reshma Taneja explores the role of lipid metabolism in cancer progression and the potential of pharmacological inhibitors to target these pathways. Lipid metabolism, which includes processes such as fatty acid synthesis, oxidation, and cholesterol synthesis, is dysregulated in cancer cells, contributing to their survival, proliferation, and resistance to therapy. The authors discuss how oncogenic signaling pathways like PI3K/AKT/mTOR, JAK/STAT, Hippo, and NF-kB intersect with lipid metabolism to drive tumor progression. They also highlight the role of epigenetic modulators in these processes and review metabolic drugs in cancer therapeutics. Key aspects covered in the article include: 1. **Overview of Lipid Metabolism**: The article provides a detailed overview of major lipid metabolic pathways, including fatty acid synthesis, oxidation, triacylglycerol synthesis and degradation, phospholipid synthesis and remodeling, cholesterol synthesis, and lipoprotein metabolism. 2. **Lipid Signalling**: It discusses the role of lipid signalling molecules in regulating various physiological functions, such as metabolism, growth, differentiation, migration, and apoptosis. Specific pathways like the PI3/AKT, arachidonic acid, sphingolipid, and AMPK pathways are highlighted. 3. **Altered Lipid Metabolism in Cancer**: The article examines how dysregulation of lipid metabolism contributes to cancer cell proliferation, invasion, and resistance to therapy. It focuses on increased fatty acid uptake, synthesis, and altered fatty acid oxidation, as well as dysregulated cholesterol metabolism. 4. **Therapeutic Avenues**: The authors explore the potential of targeting specific lipid metabolic pathways and enzymes as therapeutic strategies. They discuss the efficacy of antibodies and small-molecule inhibitors targeting fatty acid transporters, fatty acid synthases, and other key enzymes involved in lipid metabolism. 5. **Epigenetic Modifications**: The article also delves into the link between epigenetics and metabolic alterations in cancer, highlighting how epigenetic modifications can influence lipid metabolism and cancer progression. Overall, the article provides a comprehensive review of the role of lipid metabolism in cancer and the potential of pharmacological interventions to target these pathways for therapeutic benefit.The article "Targeting Dysregulated Lipid Metabolism in Cancer with Pharmacological Inhibitors" by Amogh Gupta, Dipanwita Das, and Reshma Taneja explores the role of lipid metabolism in cancer progression and the potential of pharmacological inhibitors to target these pathways. Lipid metabolism, which includes processes such as fatty acid synthesis, oxidation, and cholesterol synthesis, is dysregulated in cancer cells, contributing to their survival, proliferation, and resistance to therapy. The authors discuss how oncogenic signaling pathways like PI3K/AKT/mTOR, JAK/STAT, Hippo, and NF-kB intersect with lipid metabolism to drive tumor progression. They also highlight the role of epigenetic modulators in these processes and review metabolic drugs in cancer therapeutics. Key aspects covered in the article include: 1. **Overview of Lipid Metabolism**: The article provides a detailed overview of major lipid metabolic pathways, including fatty acid synthesis, oxidation, triacylglycerol synthesis and degradation, phospholipid synthesis and remodeling, cholesterol synthesis, and lipoprotein metabolism. 2. **Lipid Signalling**: It discusses the role of lipid signalling molecules in regulating various physiological functions, such as metabolism, growth, differentiation, migration, and apoptosis. Specific pathways like the PI3/AKT, arachidonic acid, sphingolipid, and AMPK pathways are highlighted. 3. **Altered Lipid Metabolism in Cancer**: The article examines how dysregulation of lipid metabolism contributes to cancer cell proliferation, invasion, and resistance to therapy. It focuses on increased fatty acid uptake, synthesis, and altered fatty acid oxidation, as well as dysregulated cholesterol metabolism. 4. **Therapeutic Avenues**: The authors explore the potential of targeting specific lipid metabolic pathways and enzymes as therapeutic strategies. They discuss the efficacy of antibodies and small-molecule inhibitors targeting fatty acid transporters, fatty acid synthases, and other key enzymes involved in lipid metabolism. 5. **Epigenetic Modifications**: The article also delves into the link between epigenetics and metabolic alterations in cancer, highlighting how epigenetic modifications can influence lipid metabolism and cancer progression. Overall, the article provides a comprehensive review of the role of lipid metabolism in cancer and the potential of pharmacological interventions to target these pathways for therapeutic benefit.