This review explores the role of nutraceuticals in modulating oxidative stress and inflammation, which are key factors in metabolic and cardiometabolic disorders. Metabolic disorders, characterized by conditions such as obesity, type 2 diabetes, dyslipidemia, and hypertension, pose significant health challenges globally. Traditional therapeutic approaches often fall short in managing these conditions, leading to increased interest in nutraceuticals. Nutraceuticals, derived from natural sources, exhibit potential therapeutic benefits and can support or replace pharmacological treatments, especially for individuals who do not qualify for conventional pharmacological interventions. The review highlights various nutraceutical agents, including polyphenols, omega-3 fatty acids, and antioxidants, which have antioxidative and anti-inflammatory properties. These compounds can be classified as novel nutraceutical-based drugs that regulate pathways to mitigate oxidative stress and inflammation associated with metabolic diseases. By exploring the mechanisms through which nutraceuticals interact with oxidative stress pathways and immune responses, the review underscores their potential to restore redox balance and temper chronic inflammation. Additionally, the review discusses the challenges and prospects of nutraceutical-based interventions, including bioavailability enhancement, personalized treatment approaches, and clinical translation. The article emphasizes the potential of nutraceutical-based pharmacological treatment modulation as a novel avenue to combat oxidative stress and inflammation in metabolic disorders, particularly in cardiovascular health. Recent research and clinical trials support the efficacy of nutraceuticals in managing metabolic disorders, highlighting their impact on reducing oxidative stress, inflammation, and improving metabolic health. Keywords: inflammation; oxidative stress; nutraceuticals; polyphenols; metabolic disordersThis review explores the role of nutraceuticals in modulating oxidative stress and inflammation, which are key factors in metabolic and cardiometabolic disorders. Metabolic disorders, characterized by conditions such as obesity, type 2 diabetes, dyslipidemia, and hypertension, pose significant health challenges globally. Traditional therapeutic approaches often fall short in managing these conditions, leading to increased interest in nutraceuticals. Nutraceuticals, derived from natural sources, exhibit potential therapeutic benefits and can support or replace pharmacological treatments, especially for individuals who do not qualify for conventional pharmacological interventions. The review highlights various nutraceutical agents, including polyphenols, omega-3 fatty acids, and antioxidants, which have antioxidative and anti-inflammatory properties. These compounds can be classified as novel nutraceutical-based drugs that regulate pathways to mitigate oxidative stress and inflammation associated with metabolic diseases. By exploring the mechanisms through which nutraceuticals interact with oxidative stress pathways and immune responses, the review underscores their potential to restore redox balance and temper chronic inflammation. Additionally, the review discusses the challenges and prospects of nutraceutical-based interventions, including bioavailability enhancement, personalized treatment approaches, and clinical translation. The article emphasizes the potential of nutraceutical-based pharmacological treatment modulation as a novel avenue to combat oxidative stress and inflammation in metabolic disorders, particularly in cardiovascular health. Recent research and clinical trials support the efficacy of nutraceuticals in managing metabolic disorders, highlighting their impact on reducing oxidative stress, inflammation, and improving metabolic health. Keywords: inflammation; oxidative stress; nutraceuticals; polyphenols; metabolic disorders