This review explores the role of nutraceuticals in modulating oxidative stress and inflammation in metabolic and cardiometabolic disorders. Metabolic disorders, such as obesity, type 2 diabetes, dyslipidemia, and hypertension, are characterized by oxidative stress and chronic inflammation, which contribute to global health challenges. Traditional therapies often fail to adequately address these complex conditions, prompting increased interest in nutraceuticals as potential alternatives. Nutraceuticals, derived from natural sources, have shown therapeutic benefits in reducing oxidative stress and inflammation, offering a novel approach to managing metabolic diseases. The review highlights various nutraceutical agents, including polyphenols, omega-3 fatty acids, and antioxidants, which exhibit antioxidant and anti-inflammatory properties. These compounds can regulate pathways to mitigate oxidative stress and inflammation-associated metabolic diseases. The review discusses the mechanisms through which nutraceuticals interact with oxidative stress pathways and immune responses, emphasizing their potential to restore redox balance and reduce chronic inflammation. Challenges and prospects of nutraceutical-based interventions are also addressed, including bioavailability enhancement, personalized treatment approaches, and clinical translation. Nutraceuticals such as polyphenols, curcumin, and omega-3 fatty acids have shown significant efficacy in regulating oxidative stress, inflammation, and insulin resistance. They offer a holistic strategy to combat oxidative and inflammatory challenges in metabolic disorders, potentially enhancing the effectiveness of conventional treatments. The review also discusses the potential of algae-derived nutraceuticals, which are rich in bioactive compounds with health benefits. Additionally, the role of nutraceuticals in targeting specific molecular pathways, such as the NF-κB and Nrf2 signaling pathways, is highlighted. The review concludes that nutraceuticals hold promise for the prevention, treatment, and support of metabolic disorders, particularly in improving cardiovascular health. However, further research is needed to optimize their bioavailability, personalize interventions, and ensure their safety and efficacy. Nutraceuticals, along with ongoing research, offer a comprehensive approach to enhancing metabolic health by targeting various intricate pathways associated with oxidative stress and inflammation.This review explores the role of nutraceuticals in modulating oxidative stress and inflammation in metabolic and cardiometabolic disorders. Metabolic disorders, such as obesity, type 2 diabetes, dyslipidemia, and hypertension, are characterized by oxidative stress and chronic inflammation, which contribute to global health challenges. Traditional therapies often fail to adequately address these complex conditions, prompting increased interest in nutraceuticals as potential alternatives. Nutraceuticals, derived from natural sources, have shown therapeutic benefits in reducing oxidative stress and inflammation, offering a novel approach to managing metabolic diseases. The review highlights various nutraceutical agents, including polyphenols, omega-3 fatty acids, and antioxidants, which exhibit antioxidant and anti-inflammatory properties. These compounds can regulate pathways to mitigate oxidative stress and inflammation-associated metabolic diseases. The review discusses the mechanisms through which nutraceuticals interact with oxidative stress pathways and immune responses, emphasizing their potential to restore redox balance and reduce chronic inflammation. Challenges and prospects of nutraceutical-based interventions are also addressed, including bioavailability enhancement, personalized treatment approaches, and clinical translation. Nutraceuticals such as polyphenols, curcumin, and omega-3 fatty acids have shown significant efficacy in regulating oxidative stress, inflammation, and insulin resistance. They offer a holistic strategy to combat oxidative and inflammatory challenges in metabolic disorders, potentially enhancing the effectiveness of conventional treatments. The review also discusses the potential of algae-derived nutraceuticals, which are rich in bioactive compounds with health benefits. Additionally, the role of nutraceuticals in targeting specific molecular pathways, such as the NF-κB and Nrf2 signaling pathways, is highlighted. The review concludes that nutraceuticals hold promise for the prevention, treatment, and support of metabolic disorders, particularly in improving cardiovascular health. However, further research is needed to optimize their bioavailability, personalize interventions, and ensure their safety and efficacy. Nutraceuticals, along with ongoing research, offer a comprehensive approach to enhancing metabolic health by targeting various intricate pathways associated with oxidative stress and inflammation.