High-reliability organizations (HROs) require effective teamwork to ensure safety and reliability, especially in healthcare. This article argues that teamwork is essential for achieving high reliability in healthcare. It describes the characteristics of teams, strategies for team training, and the critical role of teamwork in HROs. It also identifies challenges in improving teamwork in healthcare. Healthcare organizations operate in complex, high-risk environments where errors can have severe consequences. Despite this, teamwork is often lacking, leading to poor communication, inadequate conflict resolution, and poor situational awareness. The publication of "To Err Is Human" highlighted the prevalence of medical errors and the need for improved teamwork. The Institute of Medicine (IOM) recommended team training to improve patient safety. The Agency for Healthcare Research and Quality (AHRQ) has implemented team training programs, such as TeamSTEPPS, to improve teamwork and patient safety. These programs focus on developing team skills, such as communication, leadership, and feedback. Research shows that team training can improve team performance and reduce errors. Teamwork is defined by specific knowledge, skills, and attitudes (KSAs) that enable effective collaboration. These KSAs include communication, leadership, and feedback. Effective teamwork is essential in healthcare, where interdependent tasks require coordination and shared goals. HROs are characterized by hypercomplexity, tight coupling, extreme hierarchical differentiation, and compressed time. These characteristics require effective teamwork to ensure safety and reliability. Team training is essential for developing the KSAs needed for effective teamwork in healthcare. Despite the importance of teamwork, healthcare teams often function as separate entities, leading to poor communication and coordination. Team training is needed to improve teamwork and patient safety. Challenges remain in developing team training programs that are effective in healthcare. In conclusion, teamwork is essential for achieving high reliability in healthcare. Effective team training is needed to improve teamwork and patient safety. The science of teamwork is still evolving, and more research is needed to develop effective team training programs in healthcare.High-reliability organizations (HROs) require effective teamwork to ensure safety and reliability, especially in healthcare. This article argues that teamwork is essential for achieving high reliability in healthcare. It describes the characteristics of teams, strategies for team training, and the critical role of teamwork in HROs. It also identifies challenges in improving teamwork in healthcare. Healthcare organizations operate in complex, high-risk environments where errors can have severe consequences. Despite this, teamwork is often lacking, leading to poor communication, inadequate conflict resolution, and poor situational awareness. The publication of "To Err Is Human" highlighted the prevalence of medical errors and the need for improved teamwork. The Institute of Medicine (IOM) recommended team training to improve patient safety. The Agency for Healthcare Research and Quality (AHRQ) has implemented team training programs, such as TeamSTEPPS, to improve teamwork and patient safety. These programs focus on developing team skills, such as communication, leadership, and feedback. Research shows that team training can improve team performance and reduce errors. Teamwork is defined by specific knowledge, skills, and attitudes (KSAs) that enable effective collaboration. These KSAs include communication, leadership, and feedback. Effective teamwork is essential in healthcare, where interdependent tasks require coordination and shared goals. HROs are characterized by hypercomplexity, tight coupling, extreme hierarchical differentiation, and compressed time. These characteristics require effective teamwork to ensure safety and reliability. Team training is essential for developing the KSAs needed for effective teamwork in healthcare. Despite the importance of teamwork, healthcare teams often function as separate entities, leading to poor communication and coordination. Team training is needed to improve teamwork and patient safety. Challenges remain in developing team training programs that are effective in healthcare. In conclusion, teamwork is essential for achieving high reliability in healthcare. Effective team training is needed to improve teamwork and patient safety. The science of teamwork is still evolving, and more research is needed to develop effective team training programs in healthcare.