The study investigates the dynamics of cytokine storm and its correlation with disease severity in dengue infection. The researchers analyzed the temporal profiles of cytokine levels in 60 hospitalized dengue patients from Southern India, focusing on the third day after symptom onset. They found that a specific cytokine profile (elevated IL-8, IL-10, IL-6, GM-CSF, MCP-1, IL-13, and IL-4, and decreased IL-12, MIP-1β) was predictive of severe dengue in secondary infections. This imbalanced cytokine signature may inform clinical decision-making for treating severe dengue. The study also identified a panel of nine cytokines that could serve as early biomarkers for severe dengue, highlighting the importance of early detection and intervention. The findings contribute to a better understanding of the immunopathogenesis of dengue and provide potential tools for predicting and managing severe cases.The study investigates the dynamics of cytokine storm and its correlation with disease severity in dengue infection. The researchers analyzed the temporal profiles of cytokine levels in 60 hospitalized dengue patients from Southern India, focusing on the third day after symptom onset. They found that a specific cytokine profile (elevated IL-8, IL-10, IL-6, GM-CSF, MCP-1, IL-13, and IL-4, and decreased IL-12, MIP-1β) was predictive of severe dengue in secondary infections. This imbalanced cytokine signature may inform clinical decision-making for treating severe dengue. The study also identified a panel of nine cytokines that could serve as early biomarkers for severe dengue, highlighting the importance of early detection and intervention. The findings contribute to a better understanding of the immunopathogenesis of dengue and provide potential tools for predicting and managing severe cases.